国内首台迈胜质子治疗系统的TPS建模验证  

TPS Modeling Validation of the First Mevion Pencil Beam Scanning Proton Therapy System in China

作　　者：吴韦清 卢晓光 郑仁超 刘飞 胡广原 袁响林 Wu Weiqing;Lu Xiaoguang;Zheng Renchao(Department of Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Research Institution of Tsinghua University in Shenzhen,Shenzhen 518057,China)

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤科,武汉430030 [2]深圳清华大学研究院精准放射诊疗技术研发中心,深圳518057

出　　处：《华中科技大学学报(医学版)》2025年第2期234-239,共6页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：湖北省科技计划项目(No.2023BCB096)。

摘　　要：目的介绍国内首台迈胜质子治疗系统配套治疗计划系统建模验证的方法与结果。方法先根据TG-185报告设计水中SOBP(spread-out Bragg peak,展宽布拉格峰)射野,再根据TG-350报告设计水中的治疗计划,最后在患者CT图像上设计治疗计划,利用MatriXX ONE电离室矩阵分别测量各射野在水中不同深度处的平面剂量,测量结果与计划系统计算结果进行比较,误差设定为2%/2mm,验证输出剂量准确性。结果除跌落区外,SOBP射野的中心点剂量偏差小于3%,平面剂量γ分析通过率大于90%。治疗计划射野的测量结果均符合容差要求,不使用自适应光栅或使用静态自适应光栅时的射野输出剂量计算比使用动态自适应光栅时更准确。束流能量越低,剂量计算误差越大。结论根据计划系统计算和治疗系统实施的准确性要求,成功为华中科技大学同济医学院附属同济医院质子治疗系统配套治疗计划系统建模,IDD、空气束斑等基本情况与实测相符,且在计算质子放疗计划时,符合机器执行相同计划的实际表现。Objective To introduce the method and results of modeling validation of the treatment planning system used in the first Mevion proton therapy system in China.Methods The SOBP(Spread-Out Bragg Peak)beams in water were designed according to the TG-185 report.The treatment plans in water were designed according to the TG-350 report.The treatment plans of patients were designed on the CT images.The plane dose of each beam was measured by using the MatriXX ONE ionization chambers at different depths in the water,and the measurment results were compared with the TPS calculated results to verify the accuracy of the output doses,the error requirements were 2%/2 mm.Results Except for the distal fall-off position,the doses deviation at the SOBP beams center were less than 3%,and the γ analysis pass rates of plane doses were more than 90%.The measured results of the treatment plan beams were within the tolerance of deviation,and the output doses of the beams without or with static adaptive aperture were more accurate in general.With the decrease of beam energy,the error of dose calculation will increase.Conclusion According to the accuracy requirements of the planning system calculation and treatment system implementation,the proton therapy system supporting the treatment planning system has been modeled.Some basic performance such as IDD and beam spot is consistent with the actual measurement,and the TPS modeling conforms to the actual performance of the machine executing when calculating the same proton radiotherapy plan.

关 键 词：笔形束扫描 质子治疗系统 治疗计划系统 建模 验证 

分 类 号：R197.39[医药卫生—卫生事业管理] TH77[医药卫生—公共卫生与预防医学]