脊柱结核外科手术植骨材料研究进展  

Research Progress of Bone Grafting Materials for Spinal Tuberculosis Surgery

作　　者：李亚仑 董钊 浦飞飞[2] 夏平 Li Yalun;Dong Zhao;Pu Feifei(Department of Orthopedics,the Central Hospital of Wuhan,Tongji Medical College,Huazhong Universily of Science and Technology,Wuhan 430014,China;Department of Orthopedics,Wuhan Hospital of Traditional Chinese and Western Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属武汉市中心医院骨科,武汉430014 [2]华中科技大学同济医学院附属武汉中西医结合医院骨科,武汉430022 [3]武汉市第四医院脊柱外科,武汉430033

出　　处：《华中科技大学学报(医学版)》2025年第2期290-297,共8页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：武汉市卫生健康委员会科研项目(No.WX21M02)。

摘　　要：脊柱结核(spinal tuberculosis,STB)是一种以溶骨性破坏为特点的感染性疾病,具有高致残率和致死率。因此,当出现严重骨质破坏导致脊柱不稳,进而出现严重神经功能损害时,手术植骨成为必要的治疗手段。植骨材料的选择与手术效果息息相关,不同植骨材料各有其优缺点,直接决定了术后疗效和临床预后。随着植骨材料的产品迭代,复合型植骨材料的出现为临床治疗提供了更多的选择空间并极大地改善了患者的临床预后。综合患者临床背景,个体化选择植骨材料对于STB患者治疗效果具有重要意义。该文综述了植骨材料的分类(骨性材料、金属材料和生物活性材料等)、优缺点及目前发展情况,以期为临床植骨材料的选择提供参考。Spinal tuberculosis(STB)is an infectious disease characterized by osteolytic destruction,associated with high rates of disability and mortality.When severe bone destruction leads to spinal instability and subsequent significant neurological impairment,surgical bone grafting becomes a necessary treatment.The choice of bone graft material is closely related to surgical outcomes,as different materials have their respective advantages and disadvantages,which directly determine postoperative efficacy and clinical prognosis.With the continuous advancement of bone graft materials,the emergence of composite materials has expanded clinical treatment options and significantly improved patient outcomes.Tailored selection of bone graft materials based on individual patient clinical profiles is crucial for optimizing treatment efficacy in STB patients.Therefore,this article reviews the classification of bone graft materials(bone-based materials,metallic materials,and bioactive materials),their strengths and limitations,and recent developments,aiming to provide a reference for clinicians in selecting appropriate bone graft materials.

关 键 词：脊柱结核 植骨材料 骨性材料 金属材料 生物活性材料 

分 类 号：R529.2[医药卫生—内科学]