抗氧化高分子在生物医学应用中的研究进展  

Research progress in antioxidant macromolecules applied in biomedicine

作　　者：周同 张楠 石立旺 方昭[1] 张晨曦 祝纶宇[1] ZHOU Tong;ZHANG Nan;SHI Liwang;FANG Zhao;ZHANG Chenxi;ZHU Lunyu(Sinopec(Beijing)Research Institute of Chemical Industry Co.,Ltd.,Sinopec Key Laboratory of Research and Application of Medical and Hygienic Materials,Beijing 100013,China)

机构地区：[1]中石化(北京)化工研究院有限公司中国石化医用卫生材料研究与应用重点实验室,北京100013

出　　处：《石油化工》2025年第4期567-575,共9页Petrochemical Technology

基　　金：中国石油化工集团公司资助项目(223090)。

摘　　要：抗氧化剂能够延缓和/或抑制生理微环境中的氧化应激,被广泛视为一种有潜力的治疗性物质。与同类小分子抗氧化剂相比,抗氧化高分子具有更好的稳定性和更长的保留时间,因而在体内清除活性氧的能力更强。综述了含有不同抗氧化基团的常见抗氧化高分子,介绍了这些聚合物的官能团结构、活性氧清除机理、制备方法以及在生物医学领域中的应用进展,讨论了它们的优势和面对的挑战。Antioxidants have been widely regarded as a kind of potential therapeutics thanks to their capabilities of delaying and/or inhibiting oxidative stress in the pathological micro-environment.Compared with similar small molecules,antioxidant macromolecules have better stability and longer retention time,resulting in stronger reactive oxygen species(ROS)scavenging ability in vivo.Common antioxidant macromolecules with different antioxidant groups were reviewed.The structure of functional groups,mechanism of ROS scavenging,preparation methods,and application of these polymers in biomedical fields were introduced.Their advantages and challenges were further discussed.

关 键 词：抗氧化高分子 活性氧 炎症 疾病治疗 

分 类 号：TQ314[化学工程—高聚物工业]