Surfactant-free emulsion electrospinning of curcuminloaded poly(ε-caprolactone)/bovine serum albumin composite fibers for biomedical applications  

作　　者：Peng-Hui Zhu Shu-Hua Teng Peng Wang 

机构地区：[1]School of Materials Science and Physics,China University of Mining and Technology,Xuzhou 221116,China

出　　处：《Frontiers of Materials Science》2025年第1期31-40,共10页材料学前沿(英文版)

基　　金：financially supported by the Basic Research Project of Xuzhou Science and Technology Bureau(KC22004).

摘　　要：A novel and eco-friendly ethyl acetate/water solvent system was employed to create stable water-in-oil(W/O)emulsions of curcumin(Cur)-loaded poly(ε-caprolactone)(PCL)/bovine serum albumin(BSA)without the need for surfactants.The size of emulsion droplets decreased with the rise of the BSA concentration but increased with the drop of the oil-to-water(OTW)volume ratio.Upon electrospinning,the morphology of Cur-loaded PCL/BSA composites transformed from bead-like structures to uniform fibers as the BSA concentration rose from 0%(w/v)to 10%(w/v).With the enhancement of the OTW volume ratio,the composite fibers displayed an increased diameter and a consistently uniform morphology.The highest modulus of elasticity(0.198 MPa)and the largest elongation at break(199%)of fibers were achieved at the OTW volume ratio of 7:3,while the maximum tensile strength(3.83 MPa)was obtained at 8:2.Notably,the presence of BSA resulted in the superhydrophilicity of composite fibers.Moreover,all composite fibers exhibited sustained drug release behaviors,especially for those with the OTW volume ratio of 7:3,the release behavior of which was the best to match the first-order model.This study is expected to improve biofunctions of hydrophobic PCL and expand its applications in biomedical fields.

关 键 词：emulsion electrospinning surfactant-free emulsion composite fiber SUPERHYDROPHILICITY drug release 

分 类 号：TQ340.1[化学工程—化纤工业]