Role of the Thalamic Reticular Nucleus in Social Memory  

作　　者：Xue Liu Jianing Zhu Junqiang Zheng Han Xu 

机构地区：[1]Department of Psychiatry of the Second Affiliated Hospital and School of Brain Science and Brain Medicine,Zhejiang University School of Medicine,Hangzhou,310058,China [2]Nanhu Brain-computer Interface Institute,Hangzhou,311100,China [3]College of Life Sciences,Zhejiang University,Hangzhou,310058,China [4]Liangzhu Laboratory,MOE Frontier Science Center for Brain Science and Brain-machine Integration,State Key Laboratory of Brain-machine Intelligence,Zhejiang University,Hangzhou,311121,China [5]NHC and CAMS Key Laboratory of Medical Neurobiology,Zhejiang University,Hangzhou,310058,China [6]Lingang Laboratory,Shanghai,200031,China

出　　处：《Neuroscience Bulletin》2025年第2期355-358,共4页神经科学通报(英文版)

基　　金：supported by grants from the National Natural Science Foundation of China(32125018 and 32071005);Zhejiang Provincial Natural Science Foundation of China(LD24H090002);Nanhu Brain-computer Interface Institute(010904008);Innovative Research Team of High-level Local Universities in Shanghai(SHSMUZDCX20211102);Fundamental Research Funds for the Central Universities(226-2024-00133);the MOE Frontiers Science Center for Brain Science&Brain-Machine Integration of Zhejiang University.

摘　　要：Social behaviors are crucial for gregarious animals,including humans.In order to exhibit appropriate behaviors in a complex social context,such as mating,aggression,avoidance,and cooperation,individuals need to remember their previous experiences with other members and accurately recognize them when they meet again.This ability is called“social memory”[1].Many psychiatric disorders in humans,such as autism spectrum disorder,attention deficit hyperactivity disorder,and schizophrenia,are characterized by social memory impairments.Patients with these disorders,along with corresponding animal models,often show defects associated with the thalamic reticular nucleus(TRN).The TRN,a thin layer of neurons surrounding the thalamus,mainly regulates and coordinates the transfer of information between the cortex and the thalamus,playing a role in higher brain functions such as consciousness,attention,and sensory processing.However,whether the TRN is involved in social memory remains unknown.

关 键 词：exhibit appropriate behaviors social behaviors MATING social memory thalamic reticular nucleus gregarious animals autism spectrum disorderattention deficit hyperactivity disorderand psychiatric disorders 

分 类 号：R338[医药卫生—人体生理学]