不同代谢状态下Tyg-WC与心血管疾病风险相关性研究  

Study on correlation between TyG-WC and cardiovascular disease risk under different metabolic states

作　　者：秦越粤 乐昌稳 祝芬 孟娜 Qin Yueyue;Le Changwen;Zhu Fen;Meng Na(School of Medicine,Jianghan University,Wuhan,Hubei 430056,China;The Third Hospital of Wuhan,Wuhan,Hubei 430060,China;Guiqian International Hospital,Guiyang,Guizhou 550018,China)

机构地区：[1]江汉大学医学部,湖北武汉430056 [2]武汉市第三医院,湖北武汉430060 [3]贵黔国际医院,贵州贵阳550018

出　　处：《齐齐哈尔医学院学报》2025年第7期621-627,共7页Journal of Qiqihar Medical University

摘　　要：目的 探究在不同代谢状态下中国人群中TyG-WC指数与心血管疾病(CVD)的相关性。方法 纳入来自中国健康与退休纵向研究(CHARLS)的8942名的参与者,收集相关基本信息及资料,根据是否患有代谢综合征将参与者分为两组,并比较其基线特征。随后,根据公式计算TyG-WC指数,依据TyG-WC指数的四分位数进一步将参与者细分为四个亚组(Q1、Q2、Q3、Q4),并对各组的基线特征进行再次比较。采用多因素Logistic回归模型分析TyG-WC与CVD发生风险之间的关联并比较不同代谢状态下的差异,限制性立方样条分析TyG-WC和CVD之间的线性关系,受试者工作特征(ROC)曲线评估TyG-WC对CVD的预测效能。结果 在代谢综合征(MetS)人群中TyG-WC(Q4)的高值与CVD的高易感性相关联[OR=1.91,95%CI(1.58,2.31)],而在非MetS人群中差异无统计学意义。TyG-WC与CVD发生风险之间呈现出显著的非线性剂量反应关系(Poverall<0.01,Pnonlinear<0.05)。ROC曲线提示Tyg-WC在MetS人群中预测CVD风险有更好的预测性能。结论 TyG-WC指数可作为预测CVD风险的有效指标,并在MetS人群有着更强的识别能力。Objective To investigate the association between TyG-WC index and cardiovascular disease(CVD)in the Chinese population under different metabolic states.Methods A total of 8942 participants from the China Health and Retirement Longitudinal Study(CHARLS)were included.Relevant basic information and data were collected.Participants were divided into two groups based on the presence or absence of metabolic syndrome,and their baseline characteristics were compared.Subsequently,the TyG-WC index was calculated according to the formula,and participants were further subdivided into four subgroups(Q1,Q2,Q3,Q4)based on the quartiles of the TyG-WC index,with the baseline characteristics of each subgroup being compared again.A multifactorial logistic regression model was used to analyze the association between TyG-WC and the risk of CVD and to compare differences under different metabolic states.Restricted cubic spline analysis was performed to assess the linear relationship between TyG-WC and CVD.The area under the receiver operating characteristic(ROC)curve was used to evaluate the predictive performance of TyG-WC for CVD.Results In the metabolic syndrome(MetS)population,high values of TyG-WC(Q4)were associated with a higher susceptibility to CVD[OR=1.91,95%CI(1.58,2.31)],while no statistical difference was observed in the non-MetS population.A significant nonlinear dose-response relationship was observed between TyG-WC and the risk of CVD(Poverall<0.01,Pnonlinear<0.05).The ROC curve indicated that TyG-WC had better predictive performance for CVD risk in the MetS population.Conclusions The TyG-WC index can serve as an effective indicator for predicting CVD risk and has stronger identification ability in the MetS population.

关 键 词：代谢综合征 心血管疾病 TyG-WC指数 回顾性研究 中国健康与退休纵向研究 

分 类 号：R54[医药卫生—心血管疾病]