基于横断面数据分析尿硒水平与广西壮族妇女早绝经的关联  

Association between urinary selenium level and early menopause in Zhuang women in Guangxi based on cross-sectional analysis

作　　者：陆佩妮 许雪梅 韦港杰 黄泫茜 苏莉[1] 黄东萍 曾小云[1] 仇小强[1] 刘顺[3] LU Peini;XU Xuemei;WEI Gangjie;HUANG Xuanqian;SU Li;HUANG Dongping;ZENG Xiaoyun;QIU Xiaoqiang;LIU Shun(Department of Epidemiology,School of Public Health,Guangxi Medical University,Nanning 530021,China;Department of Sanitary Chemistry,School of Public Health,Guangxi Medical University,Nanning 530021,China;Department of Maternal,Child and Adolescent Health,School of Public Health,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学公共卫生学院流行病学教研室,南宁530021 [2]广西医科大学公共卫生学院卫生化学教研室,南宁530021 [3]广西医科大学公共卫生学院儿少卫生与妇幼保健教研室,南宁530021

出　　处：《广西医科大学学报》2025年第2期289-295,共7页Journal of Guangxi Medical University

基　　金：国家重点研发计划资助项目(No.2017YFC0907103)。

摘　　要：目的:分析广西壮族女性尿硒(Se)水平与早绝经(EM)的关联,为EM的预防提供科学依据。方法:基于“广西少数民族自然人群慢性病前瞻性队列研究”的基线资料,使用电感耦合等离子体质谱法(ICP-MS)检测尿Se浓度,根据自我报告的绝经年龄将研究对象分为自然EM组和非EM,利用logistic回归模型分析尿Se水平与EM的关联,使用趋势性检验评估尿Se浓度与EM的剂量—反应关系。结果:共纳入2394例研究对象,其中EM组155例,非EM组2239例。在全部研究对象中,未发现尿Se水平与EM的关联(OR=0.98,95%CI:0.73~1.31)。然而,将研究对象限制在55岁以下时,发现尿Se浓度与EM发生风险呈正相关(OR=1.82,95%CI:1.10~3.01);与第一分位数尿Se浓度相比,第四分位数尿Se浓度显著增加EM的发生风险(OR=2.61,95%CI:1.19~5.68)。倾向性评分匹配后,第四分位数尿Se浓度仍显著增加EM的发生风险(OR=8.29,95%CI:1.40~49.01),并且趋势性检验具有统计学意义(P<0.05)。结论:尿Se升高可能增加女性EM的发生风险。Objective:To analyze the association between urinary selenium(Se)level and early menopause(EM)in Zhuang women in Guangxi,and to provide evidence for preventing the occurrence of EM.Methods:Based on the baseline data of the“Prospective Cohort Study of Chronic Diseases in Guangxi Natural Minority Population”,inductively coupled plasma mass spectrometry(ICP-MS)was used to detect the concentration of selenium in urine.According to the self-reported age at menopause,participants were divided into EM group and non-EM group.The association between urinary Se level and EM was analyzed by logistic regression model,and the trend test was used to evaluate the dose-response relationship between urinary Se concentration and EM.Results:A total of 2,394 participants were included in the study,with 155 in the EM group and 2,239 in the non-EM group.No association was found between urinary Se levels and EM in all subjects(OR=0.98,95%CI:0.73-1.31).However,when the participants were restricted to under 55 years old of age,urinary Se concentration was found to be positively associated with the risk of EM occurrence(OR=1.82,95%CI:1.10-3.01),and urinary Se concentration in the fourth quantile significantly increased the risk of EM occurrence compared to that in the first quantile(OR=2.61,95%CI:1.19-5.68).After propensity score matching,urinary Se concentration in the fourth quantile still significantly increased the risk of EM occurrence(OR=8.29,95%CI:1.40-49.01).The trend test was statistically significant(P<0.05).Conclusion:Elevated urinary Se concentration may increase the risk of EM in women.

关 键 词：壮族 尿硒 早绝经 

分 类 号：R715[医药卫生—妇产科学]