SOX5在骨代谢和骨病预防中的作用及与运动的相互关系  

Roles of SOX5 in bone metabolism and prevention of bone diseases and the relationship with exercise

作　　者：李志鹏 邢荣鑫 胡亮红 Li Zhipeng;Xing Rongxin;Hu Lianghong(Guangxi Normal University for Nationalities,Chongzuo 532200,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西民族师范学院,广西壮族自治区崇左市532200

出　　处：《中国组织工程研究》2025年第35期7589-7600,共12页Chinese Journal of Tissue Engineering Research

基　　金：江西省教育厅科技计划重点项目(GJJ170627);广西职业教育教学改革研究项目重点项目(GXGZJG2024A028)。

摘　　要：背景:SOX5是SOX(SRY-related HMG-box)家族的重要转录因子,通过其特有的HMG盒DNA结构域协同SOX6和SOX9,在调控骨发育和重塑相关基因表达中起关键作用,特别是在成骨细胞分化和软骨细胞成熟过程中。此外,SOX5及其家族的表达和活性受多种疾病和不同形式的运动等因素调控,这表明SOX5及其家族未来有可能作为药物和治疗手段有效改善相关疾病。目的:为未来关于SOX5的研究提供新视角,并为运动干预和药物治疗在骨病预防和治疗中的应用提供科学依据。方法:检索中国知网和PubMed数据库,以“SRY-related HMG-box5,SOX5,Bone”为英文检索词,以“SRY-box转录因子5,SOX5,骨”为中文检索词,检索2001年至2024年6月发表的所有相关文献,并对其进行筛选、归纳、分析、总结,最后纳入105篇文献进行综述。结果与结论:①SOX5在骨发育中的作用:SOX5是SOX家族的重要成员,在调控骨骼发育、骨代谢和软骨形成中发挥核心作用。与SOX6和SOX9协同,SOX5通过结合特定DNA序列,激活成骨细胞和软骨细胞的基因表达,调控骨形成和骨重塑过程。②SOX5的异常表达与骨关节疾病如软骨发育不良、骨质疏松和骨关节炎等密切相关,表明它可能是这些疾病的关键调控因子,目前多种药物可能是通过调节SOX5及其家族来治疗骨代谢相关疾病,在骨组织工程中,上调间充质干细胞中SOX5可能有效改善骨代谢疾病患者的症状。③运动可以通过增强骨代谢,促进成骨细胞分化和骨密度增加,从而有效预防骨质疏松和相关骨疾病。这种作用机制可能与SOX5的具体调控机制有关,尤其是在不同类型、强度和持续时间的运动需要进一步探索研究。综上,SOX5在骨发育、软骨形成以及骨病预防中具有重要的调控作用,其活性受到多种因素的调控,而运动干预为骨病的治疗提供了新的科学依据。BACKGROUND:SOX5 is an important transcription factor of the SRY-related HMG-box(SOX)family,which plays a key role in regulating the expression of genes related to bone development and remodeling,especially during osteoblast differentiation and chondrocyte maturation,through its unique HMG box DNA structural domains in concert with SOX6 and SOX9.In addition,the expression and activity of SOX5 and its family are regulated by a variety of diseases and different forms of exercise,among other factors,suggesting that SOX5 and its family have the potential to be effective as drugs and therapeutics to ameliorate related diseases in the future.OBJECTIVE:To provide new perspectives for future research on SOX5 and to provide scientific basis for the application of exercise intervention and drug therapy in the prevention and treatment of bone diseases.METHODS:CNKI and PubMed databases were searched for relevant literature published from 2001 to June 2024,and the search terms were“SRY-related HMG-box5,SOX5,Bone”in Chinese and English,respectively.After screening,analysis and summarization,105 articles were included in the final review.RESULTS AND CONCLUSION:(1)Role of SOX5 in bone development:SOX5 is an important member of the SOX family,which plays a central role in the regulation of skeletal development,bone metabolism and cartilage formation.In synergy with SOX6 and SOX9,SOX5 activates gene expression in osteoblasts and chondrocytes by binding to specific DNA sequences to regulate bone formation and bone remodeling.(2)Abnormal expression of SOX5 is closely related to bone and joint diseases such as chondrodysplasia,osteoporosis and osteoarthritis,suggesting that it may be a key regulator of these diseases.Currently,a variety of drugs may be used to treat bone metabolism-related diseases by regulating SOX5 and its family,and upregulation of SOX5 in mesenchymal stem cells may be effective in improving the symptoms of bone metabolism disease patients in bone tissue engineering.(3)Exercise may effectively prevent osteoporo

关 键 词：SOX5 转录因子 软骨发育 炎症 骨骼重塑 骨代谢 运动 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] Q441[生物学—生理学]