脂肪自噬、运动干预与非酒精性脂肪肝的防治  

Lipophagy,exercise intervention and prevention and treatment of nonalcoholic fatty liver disease

作　　者：纪龙 陈子扬 靳攀 孔祥魁 蒲锐 Ji Long;Chen Ziyang;Jin Pan;Kong Xiangkui;Pu Rui(College of Education and Sports Sciences,Yangtze University,Jingzhou 434023,Hubei Province,China;Human Science Laboratory of Exercise,Yangtze University,Jingzhou 434023,Hubei Province,China;Health Science Center,Yangtze University,Jingzhou 434023,Hubei Province,China)

机构地区：[1]长江大学教育与体育学院,湖北省荆州市434023 [2]长江大学运动人体科学实验室,湖北省荆州市434023 [3]长江大学医学部,湖北省荆州市434023

出　　处：《中国组织工程研究》2025年第35期7611-7619,共9页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81860386),项目负责人:靳攀;2022荆州市医疗卫生科技计划项目(2022HC36),项目负责人:靳攀;2024长江大学社科基金青年项目(2024csq006),项目负责人:陈子扬。

摘　　要：背景:脂肪自噬与多种慢性代谢性疾病密切相关,运动能够调控脂肪自噬延缓非酒精性脂肪肝的病理进程,已成为运动医学和生命科学领域中热门的研究之一。目的:总结脂肪自噬对非酒精性脂肪肝的调控作用,以及运动介导脂肪自噬在改善非酒精性脂肪肝中的机制。方法:检索1980-2025年中国知网和PubMed、Web of Science数据库的相关文献,中文检索词包括“脂肪自噬、脂质代谢、非酒精性脂肪肝、有氧运动、抗阻运动、有氧联合抗阻运动”;英文检索词包括“lipophagy,lipid metabolism,non-alcoholic fatty liver disease,aerobic exercise,resistance training,combined aerobic resistance exercise”,根据纳入和排除标准选择98篇文献进行归纳总结。结果与结论:①脂肪自噬在非酒精性脂肪肝的防治中发挥着重要的调控作用;②不同运动方式均对脂肪自噬产生影响:有氧运动能够调节脂肪自噬相关因子的表达、增加自噬通量、提高溶酶体生物合成和促进脂肪酶分解,在脂肪自噬的调控中发挥有益效应;抗阻运动可提高脂肪自噬相关因子的表达;有氧联合抗阻运动能够提高脂肪的氧化率和改善胰岛素敏感性;③运动可通过改善肝脏炎症、胰岛素抵抗以及提升肝脏功能从而治疗非酒精性脂肪肝;④运动通过调控脂肪自噬减少脂质蓄积、抑制脂肪变性、减缓肝脏炎症和纤维化及改善胰岛素抵抗,在防治非酒精性脂肪肝中发挥关键作用。BACKGROUND:Lipophagy is closely related to a variety of chronic metabolic diseases.Exercise can delay the pathological process of non-alcoholic fatty liver by regulating lipophagy,which has become one of the most popular studies in the field of sports medicine.OBJECTIVE:To summarize the regulatory role of lipophagy in non-alcoholic fatty liver disease and the mechanism of exercise-mediated lipophagy in nonalcoholic fatty liver disease.METHODS:CNKI,PubMed,and Web of Science databases were searched for relevant literature published from 1980 to 2025,using the search terms of“lipophagy,lipid metabolism,non-alcoholic fatty liver disease,aerobic exercise,resistance training,combined aerobic resistance exercise”in Chinese and English.Totally 98 documents were included according to inclusion and exclusion criteria.RESULTS AND CONCLUSION:(1)Lipophagy plays an important regulatory role in the prevention and treatment of non-alcoholic fatty liver disease.(2)Different types of exercises affect lipophagy:Aerobic exercise can play a beneficial role can regulate the expression of lipophagy related factors,enhance autophagy flow,improve lysosome biosynthesis and promote the decomposition of lipase.Resistance training can increase the expression of autophagy related factors in adipose tissue.Combined aerobic resistance exercise can increase fat oxidation rate and improve insulin sensitivity.(3)Exercise can treat non-alcoholic fatty liver disease by improving liver inflammation,insulin resistance,and liver function.(4)Exercise plays a key role in the prevention and treatment of non-alcoholic fatty liver by regulating lipophagy,reducing lipid accumulation,inhibiting steatosis,alleviating liver inflammation and fibrosis and improving insulin resistance.

关 键 词：脂肪自噬 脂质代谢 因子 非酒精性脂肪肝 有氧运动 抗阻运动 有氧联合抗阻运动 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R575