线粒体DNA与心房颤动的相关性研究进展  

The Relationship Between Mitochondrial DNA and Atrial Fibrillation

作　　者：王东晓 石雅晴 冯露 王立立[1] WANG Dongxiao;SHI Yaqing;FENG Lu;WANG Lili(Department of Cardiovascular Medicine,Hebei General Hospital,Shijiazhuang 050000,Hebei,China)

机构地区：[1]河北省人民医院心血管内科,河北石家庄050000

出　　处：《心血管病学进展》2025年第4期314-317,共4页Advances in Cardiovascular Diseases

摘　　要：心房颤动是临床上比较常见的一种心律失常,是引发重要脏器栓塞的主要危险因素,在全球范围内发病率逐渐上升。随着生物技术的发展,越来越多的证据表明心房颤动与线粒体DNA(mtDNA)改变有关,现从mtDNA功能障碍参与心房颤动的病理生理机制、mtDNA突变、mtDNA缺失、mtDNA的拷贝数等方面阐明mtDNA在心房颤动中的作用及其调控机制,对于患者预后的评估以及发掘治疗心房颤动的新靶点具有重要的临床意义。Atrial fibrillation is a common arrhythmia in clinical practice and a major risk factor for important organ embolism.The incidence rate of atrial fibrillation is gradually rising worldwide.With the development of biotechnology,more and more evidence suggests that atrial fibrillation is related to changes in mitochondrial DNA(mtDNA).Now,the role and regulatory mechanism of mtDNA in atrial fibrillation are elucidated from the aspects of mtDNA dysfunction,mtDNA mutations,mtDNA deletions,mtDNA copy number,etc.This has important clinical significance for evaluating patient prognosis and discovering new targets for the treatment of atrial fibrillation.

关 键 词：心血管病学 心房颤动 线粒体DNA 

分 类 号：R541.7[医药卫生—心血管疾病]