线粒体质量控制在阿霉素诱导的心脏毒性中的研究进展  

Mitochondrial Quality Control in Doxorubicin Cardiotoxicity

作　　者：王心雨 王钰淇 罗皓文 常盼[1,2] 赵晓红 WANG Xinyu;WANG Yuqi;LUO Haowen;CHANG Pan;ZHAO Xiaohong(Department of Anesthesia,Second Clinical Medical College,Xi’an Medical University,Xi’an 710038,Shaanxi,China;Department of Basic Medical Sciences,Air Force Medical University,Xi’an 710036,Shaanxi,China)

机构地区：[1]西安医学院第二临床医学院麻醉系,陕西西安710038 [2]空军军医大学基础医学部,陕西西安710036

出　　处：《心血管病学进展》2025年第4期318-321,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(82300407);国家资助博士后研究人员计划(GZC20233580);陕西省科技厅自然基础重点项目(2023-JC-ZD-55);陕西省教育厅2023年度服务地方专项科学研究计划(23JC059);2023年省级大学生创新创业训练计划项目(S202311840059)。

摘　　要：阿霉素是一种广谱抗肿瘤药,其对多种恶性肿瘤具有明确疗效,但严重的心脏毒性限制了该药物的临床应用前景。线粒体质量控制通过线粒体生物发生、线粒体动力学和线粒体自噬等途径,维持线粒体稳态,调控线粒体功能,参与心肌损伤与修复。多项研究表明,线粒体质量控制在阿霉素诱导的心脏毒性中发挥重要作用,但潜在的分子机制仍需要进一步研究。现对近年来发现的线粒体质量控制在阿霉素心脏毒性中的作用及机制做一综述,旨在通过阐明线粒体质量控制在阿霉素心脏毒性中的作用,为预防阿霉素相关心脏毒性指明方向以及发现潜在的治疗靶点。Doxorubicin is a broad-spectrum antitumor drug with clear efficacy against a variety of malignancies,but severe cardiotoxicity limits the clinical application prospect of the drug.Mitochondrial quality control maintains mitochondrial homeostasis,regulates mitochondrial function,and participates in myocardial injury and repair through mitochondrial biogenesis,mitochondrial dynamics,and mitophagy.Several studies have shown that mitochondrial quality control plays an important role in the cardiotoxic effects of doxorubicin,but the underlying molecular mechanisms still require further investigation.This article reviews the role and mechanism of mitochondrial quality control in doxorubicin cardiotoxicity discovered in recent years.It aims to elucidate the role of mitochondrial quality control in doxorubicin cardiotoxicity,to provide direction for the prevention of doxorubicin-related cardiotoxicity and to identify potential therapeutic targets for cardiotoxicity.

关 键 词：阿霉素 线粒体质量控制 心脏毒性 

分 类 号：R96[医药卫生—药理学]