RNA结合基序蛋白介导的可变剪接在心力衰竭中的作用机制进展  

Mechanism of RNA Binding Motif Protein Mediated Alternative Splicing in Heart Failure

作　　者：张可意 杨萍[1] ZHANG Keyi;YANG Ping(Department of Cardiology,The First Affiliated Hospital of Kunming Medical University,Kunming 650000,Yunnan,China)

机构地区：[1]昆明医科大学第一附属医院心脏内科,云南昆明650000

出　　处：《心血管病学进展》2025年第4期327-331,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(82360082,81760074);云南省科技厅-昆明医科大学应用基础研究联合专项项目(202201AY070001-064);云南省中青年学术和技术带头人后备人才项目(202305AC160048);云南省心脑血管疾病临床医学中心资助项目(ZX2019-03-01)。

摘　　要：可变剪接(AS)是一种转录后机制,通过单一基因生成多样的蛋白质异构体,其主要功能是移除内含子并连接外显子,进而形成成熟的信使RNA(mRNA)。RNA结合蛋白质(RBP),是一类伴随RNA的调控代谢过程,与RNA结合的蛋白质的总称,是调控AS的关键因素。它们通过识别特定的序列元件并绑定到前信使RNA(pre-mRNA)上,从而影响剪接位点的选择,进而导致一些疾病相关基因的异常表达或功能失调。RNA结合基序蛋白是RBP家族中的重要一类,它在心力衰竭中通过调控心肌细胞AS模式,从而发挥重要作用。Alternative splicing(AS)is a post-transcriptional mechanism that generates diverse protein isoforms from a single gene.Its main function is to remove introns and link exons to form mature messenger RNA(mRNA).RNA binding protein(RBP)are a class of proteins that regulate the metabolic process of RNA binding and are collectively referred to as proteins that bind to RNA.They are a key factor in regulating AS.They affect the choice of splicing sites by recognizing specific sequence elements and binding to the precursor mRNA(premRNA).This leads to abnormal expression or dysfunction of some disease-related genes.RNA binding motif protein(RBM)are an important class of RBP,and they play an important role in heart failure by regulating the AS pattern of cardiomyocytes.

关 键 词：可变剪接 RNA结合基序蛋白20 RNA结合基序蛋白24 RNA结合基序蛋白25 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]