巨噬细胞在急性心肌梗死发展和治疗中的研究进展  

Role of Macrophages in the Development and Treatment of Acute Myocardial Infarction

作　　者：全金海 李上海 梁伟钧 QUAN Jinhai;LI Shanghai;LIANG Weijun(The Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,Guangdong,China)

机构地区：[1]广东医科大学附属医院,广东湛江524000

出　　处：《心血管病学进展》2025年第4期332-335,共4页Advances in Cardiovascular Diseases

基　　金：湛江市科技计划项目(2022A01187)。

摘　　要：急性心肌梗死(AMI)及其诱发的心力衰竭是全球主要致残和致死原因之一。虽然血运重建与药物治疗技术不断提升,但AMI的致死率仍居高不下。炎症在这一过程中扮演着重要角色,其中,单核细胞与巨噬细胞作为先天免疫系统的多效性细胞,在损伤初始炎症反应与后续愈合中起着关键作用。因此,深入理解巨噬细胞在AMI发展中的作用,对于治疗和改善患者预后至关重要。现对巨噬细胞在AMI发展中的作用及治疗研究进展进行综述。Acute myocardial infarction(AMI)and its induced heart failure are one of the leading causes of death and disability worldwide.Despite increasing revascularization and drug therapy,the mortality of AMI remains high.Inflammation plays an important role in this process,in which monocytes and macrophages,as pleiotropic cells of the innate immune system,play a key role in the initial inflammatory response to injury and subsequent healing.Therefore,a deeper understanding of the role of macrophages in the development of AMI is essential both for treating patients and for improving patient outcomes.This paper will review the role of macrophages in the development of acute myocardial infarction and the progress of therapeutic research.

关 键 词：心肌梗死 巨噬细胞 免疫反应 炎症 

分 类 号：R542.2[医药卫生—心血管疾病]