窄带中波紫外光疗致皮肤癌的研究进展  

Research Progress of Skin Cancer Induced by Narrow-Band Ultraviolet Phototherapy

作　　者：陈东亚 谭一舟 谯煜 顾瑛 CHEN Dongya;TAN Yizhou;QIAO Yu;GU Ying(Medical School of Chinese PLA,Beijing 100853,China;Department of Laser Medicine,the First Medical Center of Chinese PLA General Hospital;Laser Medicine Center,Hainan Hospital of Chinese PLA General Hospital;Precision Laser Medical Diagnosis and Treatment Innovation Unit,Chinese Academy of Medical Sciences)

机构地区：[1]解放军医学院,北京市100853 [2]中国人民解放军总医院第一医学中心激光医学科 [3]中国人民解放军总医院海南医院激光医学中心 [4]中国医学科学院精准激光医学诊疗创新单元

出　　处：《中国激光医学杂志》2025年第1期43-49,共7页Chinese Journal of Laser Medicine & Surgery

基　　金：国家重点研发计划(2017YFB0403801);中国医学科学院医学与健康科技创新工程项目资助(2019-12M-5-061)。

摘　　要：窄带中波紫外光疗已在世界各地被广泛用于治疗银屑病、白癜风等难治性皮肤疾病,近年来也用于促进人体皮肤合成维生素D,且在动物实验和临床试验中均取得了显著效果。各种新型光源的出现则进一步推动了紫外光疗的临床应用和家庭光疗的开展,但是窄带中波紫外光疗的临床应用的安全性尤其是致癌性也越来越受到人们的关注。本文对近年来窄带中波紫外光疗致皮肤癌的相关临床和基础研究进行了综述,发现目前临床研究中并无窄带中波紫外光疗致癌的依据,动物实验却证实了长期接受窄带中波紫外光可致癌。本文进一步概述了窄带中波紫外光疗致癌的可能机制及早期评估方法,拟为临床医师更好地指导患者正确选择和使用窄带中波紫外光疗提供依据。Narrow-band UVB phototherapy has been widely used in the treatment of psoriasis,vitiligo and other refractory skin diseases all over the world.In recent years,it has been used to synthesize vitamin D,and remarkable results have been achieved in animal and clinical trials.The emergence of various new light sources has greatly promoted the clinical application of ultraviolet phototherapy and the further development of home phototherapy,but the safety of narrow-band UVB phototherapy in clinical application,especially the carcinogenic property,has also attracted more and more attentions.Is this article the clinical and basic research on skin cancer induced by narrow-band UVB phototherapy in recent years were reviewed.No evidence has been found to link narrow-band UVB phototherapy with cancer in clinical studies,but it has been confirmed via animal experiments that long-term exposure to NB-UVB will cause cancer.Furthermore,the possible mechanism and early evaluation methods of narrow-band UVB phototherapy were also outlined hereunder for the sake of providing a basis for clinicians to better guide patients to choose and use narrow-band UVB phototherapy correctly.

关 键 词：窄带中波紫外光 致癌机制 皮肤恶性肿瘤 环丁烷嘧啶二聚体 最小红斑剂量 

分 类 号：R318.51[医药卫生—生物医学工程] Q503[医药卫生—基础医学]