纳米药物:急诊血栓性心血管疾病治疗新策略  

Nanomedicine:A new strategy for the treatment of emergency thrombotic cardiovascular diseases

作　　者：刘湘国 边圆[1,2] 袁秋环[1,2] 梅林强 徐峰[1,2] LIU Xiangguo;BIAN Yuan;YUAN Qiuhuan;MEI Linqiang;XU Feng(Department of Emergency Medicine,Qilu Hospital of Shandong University,Jinan,250012,China;Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine,Institute of Emergency and Critical Care Medicine of Shandong University,Chest Pain Center,Qilu Hospital of Shandong University)

机构地区：[1]山东大学齐鲁医院急诊科,济南250012 [2]山东省急危重症医学临床研究中心,山东大学急危重症医学研究所,山东大学齐鲁医院胸痛中心

出　　处：《临床急诊杂志》2025年第3期157-161,共5页Journal of Clinical Emergency

基　　金：山东省重点研发计划(No:2024CXPT089);山东省科技创新重大专项(No:2022CXGC010504)。

摘　　要：急诊血栓性心血管疾病的管理和治疗一直是现代医学中的一大挑战,这些疾病通常伴随有高致死率,且对药物治疗的响应性差。近年来,纳米药物由于其独特的物理化学特性和生物相容性已经逐渐成为解决急诊血栓性心血管疾病治疗难题的新策略。本文综述了纳米药物在急诊血栓性心血管疾病中的研究进展,涵盖纳米药物的设计与制备、靶向递送机制、在急诊血栓性心血管疾病中的应用以及未来的研究方向。The management and treatment of emergency thrombotic cardiovascular diseases remain a significant challenge in modern medicine.These diseases are often associated with high mortality and poor responsiveness to pharmacological interventions.In recent years,nanomedicines have emerged as a promising strategy to address the therapeutic challenges of emergency thrombotic cardiovascular diseases,owing to their unique physicochemical properties and biocompatibility.This article reviews the advancements in nanomedicine in emergency thrombotic cardiovascular diseases,covering the design and preparation of nanomedicines,targeted delivery mechanisms,applications in emergency thrombotic cardiovascular diseases,and future research directions.

关 键 词：急诊血栓性心血管疾病 纳米药物 精准靶向 

分 类 号：R541[医药卫生—心血管疾病]