HIF-1α信号通路在股骨头坏死作用的研究现状  

Current research on role of HIF-1αsignal pathway in osteonecrosis of femoral head

作　　者：郑鑫达 李波香 丁晓飞[1] 廖世杰[1] ZHENG Xin-da;LI Bo-xiang;DING Xiao-fei;LIAO Shi-jie(Department of Traumatic Orthopedics and Hand Surgery,The First Affiliated Hospital,Guangxi Medical University,Nanning,Guangxi 530021,China;Department of Orthopedics,Ethnic Hospital,Guangxi Medical University,Nanning,Guangxi 530001,China)

机构地区：[1]广西医科大学第一附属医院创伤骨科手外科,广西南宁530021 [2]广西医科大学附属民族医院骨科,广西南宁530001

出　　处：《中国矫形外科杂志》2025年第6期517-522,共6页Orthopedic Journal of China

基　　金：国家自然科学基金资助项目(编号:82060396,82160809);广西医科大学青年科学基金项目(编号:GXMUYSF202233);广西自然科学基金项目(编号:2023GXNSFAA026342);广西医科大学第一附属医院青年科技启明星计划项目(编号:YYZS2022008)。

摘　　要：股骨头坏死(osteonecrosis of the femoral head,ONFH)是骨科常见的髋部疾病之一,目前还没有明确的药物可以完全阻止ONFH的进展。近年来,HIF-1α信号通路在ONFH中的研究逐渐增多,研究发现,HIF-1α信号通路在间充质干细胞、内皮祖细胞和软骨细胞中被激活,进而刺激细胞分泌血管生成和骨修复相关细胞因子,从而促进ONFH的修复。此外许多药物也能够通过激活细胞内HIF-1α信号通路促进ONFH的骨修复和血管生成,在治疗ONFH方面具有潜在的应用价值。本文通过综述HIF-1α信号通路在ONFH作用的研究现状,为临床上治疗ONFH提供更多的方法和思路。Osteonecrosis of the femoral head(ONFH)is one of the common hip diseases in orthopaedics,and there is no definite drug that can completely prevent the development of ONFH.In recent years,the study on the role of HIF-1αsignaling pathway in ONFH has gradually increased.It has been found that HIF-1αsignaling pathway is activated in mesenchymal stem cells,endothelial progenitor cells and chondrocytes,this in turn stimulates the secretion of angiogenesis and bone repair-related cytokines to promote ONFH repair.In addition,many drugs can also promote bone repair and angiogenesis of ONFH by activating intracellular HIF-1αsignaling pathway,which has potential application value in the treatment of ONFH.In this article,we reviewed the research status of HIF-1αsignal pathway in ONFH,and provided some potential approach and ideas for clinical treatment of ONFH.

关 键 词：HIF-1α号通路 股骨头坏死 骨修复 血管生成 

分 类 号：R681.8[医药卫生—骨科学]