[足母]外翻与膝骨关节炎基因关系的孟德尔随机化研究  

A Mendelian randomized study of the genetic relationship between hallux valgus and knee osteoarthritis

作　　者：成文浩 孟林 李宏宇 李慕杨 CHENG Wenhao;MENG Lin;LI Hong-yu;LI Mu-yang(Guangxi University of Chinese Medicine,Nanning 530000,Guangxi,China;Guangxi Orthopedic Hospital,Nanning 530000,Guangxi,China)

机构地区：[1]广西中医药大学,广西南宁530000 [2]广西骨伤医院,广西南宁530000

出　　处：《中国矫形外科杂志》2025年第6期541-547,共7页Orthopedic Journal of China

基　　金：广西壮族自治区青年岐黄学者培养项目(编号:桂中医药科教发[2022]13号);广西中医药民族医药适宜技术推广与应用课题(编号:GZSY23-13);广西中医药重点研究室建设项目(桂中医药科教发[2023]9号)。

摘　　要：[目的]采用双向两样本孟德尔随机化研究探讨[足母]外翻和膝骨关节炎之间的因果关系。[方法]基于全基因组关联研究(genome-wide association study,GWAS)数据库,应用逆方差加权(inverse-variance weighted,IVW)、加权众数法(weighted mode)和MR-Egger进行双向两样本孟德尔随机化研究分析。[结果][足母]外翻是膝骨关节炎发生的危险因素,IVW结果(OR=1.14,P=0.015);膝骨关节炎也是[足母]外翻发生的危险因素,IVW结果(OR=1.65,P=1.51e-05)。双向两样本孟德尔随机化研究中均没有水平多效性的存在(P>0.05)。“留一法”分析显示,双向两样本孟德尔随机化研究的结果都是可靠的。[结论]从大样本和遗传学角度上来看,[足母]外翻是膝骨关节炎风险增加的危险因素,膝骨关节炎同样是[足母]外翻风险增加的危险因素,且两结果之间具有独立性和可靠性。[Objective]A bidirectional two-sample Mendelian randomization study was conducted to investigate the causal relationship between hallux valgus and knee osteoarthritis.[Methods]Based on GWAS(Genome-wide Association Study)database,IVW(inverse-variance weighted),weighted mode and MR-Egger were used to conduct bidirectional two-sample Mendelian randomization analysis.[Results]There was a positive causal relationship between hallux valgus and increased risk of knee osteoarthritis,with IVW(OR=1.14,95%CI:1.03~1.27,P=0.015).There was also a positive causal relationship between knee osteoarthritis and increased risk of hallux valgus with IVW(OR=1.65,95%CI:1.31~2.06,P<0.001).There was no horizontal pleiotropy in the bidirectional two-sample Mendelian randomization study(P>0.05).The results of bidirectional twosample Mendelian randomization are robust.[Conclusion]From a large sample size and genetics,hallux valgus is a risk factor for knee osteoarthritis.On other hand,knee osteoarthritis is also a risk factor for hallux valgus,and there is independence and stability between the two outcomes.

关 键 词：[足母]外翻 膝骨关节炎 因果关系 孟德尔随机化研究 

分 类 号：R684.3[医药卫生—骨科学]