具有止血活性的中药活性成分研究进展  

Research progress on the active ingredients of traditional Chinese medicine with hemostatic activity

作　　者：吴鑫茹 胡瑄 孟志云 顾若兰 甘慧 吴卓娜 窦桂芳 WU Xinru;HU Xuan;MENG Zhiyun;GU Ruolan;GAN Hui;WU Zhuona;DOU Guifang(Academy of Military Science,Beijing Institute of Radiation Medicine,Beijing 100850,China)

机构地区：[1]军事科学院军事医学研究院,北京100850

出　　处：《中华中医药杂志》2025年第3期1323-1327,共5页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：出血可能发生在机体的各个部位,轻度的出血可以依赖机体凝血机制及简单的按压实现止血,但中、重度出血时需要借助止血药物及敷料止血。止血药可以激活凝血通路或富集凝血因子促进止血,中药具有凉血、化瘀、收敛和温经的作用。中药来源的止血药物含有多种成分,具有多靶点、多途径及双向调节的特点,但在现代医学背景下,还有一些机制尚不能完全解释。本研究依据不同的中药药理作用对常用止血中药药理作用及活性成分进行阐述,并从靶点构象探讨了中药作用基础,为发掘天然药物的止血新成分提供思路。Bleeding may occur in various parts of the body.Mild bleeding can be stopped by the body's coagulation mechanism and simple pressing,but moderate and severe bleeding requires hemostatic drugs and dressings to stop bleeding.Hemostatic drugs can activate coagulation pathways or enrich coagulation factors to promote hemostasis.Traditional Chinese medicine(TCM)has the functions of cooling blood,removing blood stasis,astringency and warming meridians.Hemostatic drugs derived from TCM contain a variety of components and are characterized by multi-targets,multi-pathways and bidirectional regulation.However,some mechanisms are still not fully explained in the context of modern medicine.Based on the different pharmacological effects of TCM,this paper expounds the pharmacological effects and active components of common hemostatic TCM,and discusses the basis of action of TCM from the target conformation,so as to provide convenience for explaining the pharmacology of hemostatic TCM and provide ideas for exploring new hemostatic components of natural drugs.

关 键 词：中药 止血 活性成分 凝血因子 活性位点 结构域 

分 类 号：R285[医药卫生—中药学]