雷公藤抗白血病研究进展  

Research progress on anti-leukemia of Tripterygium wilfordii

作　　者：顾恪波[1] 何立丽[1] 张明辉[1] 张丽娜[1] 吴洁[1] 孙岸 张晨[1] 李琦玮 GU Kebo;HE Lili;ZHANG Minghui;ZHANG Lina;WU Jie;SUN Antao;ZHANG Chen;LI Qiwei(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中华中医药杂志》2025年第3期1337-1340,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中央高水平中医医院临床科研业务费(No.HLCMHPP2023018)。

摘　　要：雷公藤用于治疗风湿免疫病及肿瘤等均取得显著效果并形成研究热点,历久不衰。当前研究显示,雷公藤对白血病、淋巴瘤、骨髓瘤、再生障碍性贫血、溶血性贫血等疑难病也有一定疗效。目前发现雷公藤对急性原粒细胞白血病、急性早幼粒细胞白血病、急性粒-单核细胞白血病、急性单核细胞白血病、急性T淋巴细胞白血病、急性B淋巴细胞白血病、慢性髓系白血病以及成人T淋巴细胞白血病等有一定抑制作用,机制包括抑制转录因子Myb、调节p53-MDM2轴、抑制癌基因C-myc、调节Bcl-2家族蛋白以促进亡等。由于雷公藤对白血病有广谱拮抗作用,虽有一定毒性,但在临床只要科学掌握其用量、配伍及疗程,完全可以较好防止不良反应的发生,发挥独特疗效。因此,雷公藤治疗白血病的前景值得期待。Since the use of Tripterygium wilfordi in the treatment of rheumatological diseases and tumors,remarkable results have been achieved and research hotspots have been formed for a long time.Current research shows that Tripterygium wilfordi on leukemia,lymphoma,myeloma,aplastic anemia,hemolytic anemia and other difficult blood diseases have a certain effect.It has been found that Tripterygium wilfordi has certain inhibitory effects on acute promyelocytic leukemia,Acute promyelocytic leukemia leukemia,acute myelomonocytic leukemia,acute monocytic leukemia,acute lymphocyte leukemia,acute lymphocyte leukemia,chronic myeloid leukemia and adult lymphocyte leukemia,the mechanism includes inhibiting transcription factor Myb,regulating p53-MDM2 axis,inhibiting oncogene C-myc,regulating Bcl-2 family proteins to promote apoptosis,and so on.Because Tripterygium wilfordi has broad-spectrum antagonistic effect on leukemia,although it has certain toxicity,but in clinical as long as scientific control of its dosage,compatibility and course of treatment,and better preventing adverse reactions,it can play unique efficacy.Therefore,the prospect of Tripterygium wilfordii treatment of leukemia is worth lookingforward.

关 键 词：雷公藤 白血病 研究进展 雷公藤甲素 雷公藤红素 

分 类 号：R285[医药卫生—中药学]