二茂钛-对甲苯磺酸组合催化aza-Friedel-Crafts反应的研究  

Study of using titanocene-sulfonic acid combination to catalyze aza-Friedel-Crafts reaction

作　　者：王芸芸 王涛 杨兰 赵霄 李荣 金文慧 WANG Yun-Yun;WANG Tao;YANG Lan;ZHAO Xiao;LI Rong;JIN Wen-Hui(Ningxia Normal University,College of Chemical Engineering,Guyuan 756000,China;Ningxia Normal University,Ningxia key laboratory of green catalytic materials and technology,Guyuan 756000,China)

机构地区：[1]宁夏师范大学化学化工学院,宁夏固原756000 [2]宁夏师范大学,宁夏回族自治区绿色催化材料与技术重点实验室,宁夏固原756000

出　　处：《化学研究与应用》2025年第4期864-872,共9页Chemical Research and Application

基　　金：2024年宁夏回族自治区重点研发计划引才专项项目(2024BEH04049)资助;2024年固原市“拨改投”科技项目(2024BGTYF-47)资助;宁夏高等学校一流学科建设项目教育学学科(NXYLXK2021B10)资助;宁夏回族自治区大学生创新训练项目(0703)资助。

摘　　要：以Lewis酸协同Brφnsted acid酸为催化体系,催化aza-Friedel-Crafts反应合成一类非对称结构的3-二异芳基甲基吲哚衍生物。研究结果表明:在Cp_(2)TiCl_(2)10 mmol%,对甲苯磺酸20 mmol%,溶剂为CH_(2)Cl_(2),底物比例1.2:1:1.2(吲哚:醛:间苯二甲醚),温度为40℃,反应时间8h条件下,3-二异芳基甲基吲哚衍生物产率最高可达93%,底物普适性良好。Lewis acid and Brφnsted acid were used as catalysts to catalytic aza-Friedel-Crafts reaction and synthesis of 3-diisoarylmethylindole derivatives with asymmetric structure.The results showed that under the conditions of Cp_(2)TiCl_(2)10 mmol%,p-toluene sulfonate 20 mmol%,CH_(2)Cl_(2)solvent,1.2:1:1.2 substrate ratio(indole:aldehyde:isophthalmic ether),temperature 40℃,and reaction time 8 h,the yield of 3-diarylmethylindole derivatives was up to 93%,and the substrate had good universality.

关 键 词：3-二异芳基甲基吲哚衍生物 Cp_(2)TiCl_(2) aza-Friedel-Crafts反应 

分 类 号：O626.13[理学—有机化学]