肠道菌群代谢产物氧化三甲胺与心血管疾病关系的研究进展  

Research progress on the relationship between gut microbiota-derived metabolite trimethylamine N-oxide and cardiovascular diseases

作　　者：朱德文 陈丽娜 ZHU Dewen;CHEN Lina(Department of Cardiovascular,Shaoxing Central Hospital,Shaoxing 312000,China)

机构地区：[1]绍兴市中心医院医共体总院心血管内科,312000

出　　处：《心电与循环》2025年第2期143-148,共6页Journal of Electrocardiology and Circulation

基　　金：浙江省医药卫生科技计划项目(2024KY486)。

摘　　要：肠道菌群代谢产物氧化三甲胺(TMAO)主要通过微生物-哺乳动物共代谢途径产生,TMAO与冠心病、高血压、心力衰竭、心律失常等多种心血管疾病相关。目前,TMAO与心血管疾病的因果关系仍不明确,部分研究质疑TMAO在心血管疾病中的作用,鉴于此,本文对肠道菌群代谢产物TMAO与心血管疾病关系的研究进展作一述评。Trimethylamine N-oxide,a gut microbiota-derived metabolite primarily generated through microbialmammalian co-metabolic pathways,which has been implicated in various cardiovascular diseases,including coronary artery disease,hypertension,heart failure and arrhythmias.However,the causal relationship between trimethylamine N-oxide and cardiovascular pathologies remains controversial,some emerging studies questioning its mechanistic role in disease progression.In view of this,this article reviews the research progress on the relationship between gut microbiota-derived metabolite trimethylamine N-Oxide and cardiovascular diseases.

关 键 词：心血管疾病 肠道菌群 氧化三甲胺 

分 类 号：R54[医药卫生—心血管疾病]