原发性高血压患者颈动脉斑块形成与幽门螺杆菌感染关系  

Relationship between carotid plaque formation and helicobacter pylori infection in patients with essential hypertension

作　　者：梅夏燕 章奇绮 王东娟 MEI Xiayan;ZHANG Qiqi;WANG Dongjuan(Health Science Center,Ningbo University,Ningbo 315211,China;不详)

机构地区：[1]宁波大学医学部,315211 [2]宁波市海曙区西门望春社区卫生服务中心全科门诊 [3]宁波市第二医院心血管内科

出　　处：《心电与循环》2025年第2期177-180,共4页Journal of Electrocardiology and Circulation

摘　　要：目的探讨原发性高血压(EH)患者颈动脉斑块形成与幽门螺杆菌(Hp)感染的关系。方法回顾性选择2021年3月至2023年3月宁波市海曙区西门望春社区卫生服务中心体检的EH患者150例,按Hp检测结果分为Hp阳性组67例和Hp阴性组83例,比较两组患者一般资料、颈动脉斑块形成情况。采用Spearman秩相关分析Hp感染与颈动脉斑块形成的相关性,采用多因素logistic回归分析影响EH患者颈动脉斑块形成的危险因素。结果Hp阳性组患者舒张压、收缩压、总胆固醇(TC)、甘油三酯、空腹血糖(FBG)、C反应蛋白(CRP)及同型半胱氨酸(Hcy)水平高于Hp阴性组,差异均有统计学意义(均P<0.05)。Hp阳性组患者斑块形成占比、三级斑块占比、Crouse积分及总斑块负荷高于Hp阴性组,差异均有统计学意义(均P<0.05)。Spearman秩相关分析显示,Hp感染与斑块形成及Crouse积分呈正相关(r_(s)=0.292、0.234,均P<0.05)。多因素logistic回归分析显示,TC、FBG、CRP及Hcy水平均为影响EH患者颈动脉斑块形成的独立危险因素(均P<0.05)。结论Hp感染与EH患者颈动脉斑块之间存在弱相关。Objective To explore the relationship between carotid plaque formation and Helicobacter pylori(Hp)infection in patients with essential hypertension(EH).Methods A total of 150 EH patients who received physical examination in Haishu District Ximen Wangchun Community Health Service Center were retrospectively selected from March 2021 to March 2023.The patients were divided into Hp-positive group(67 cases)and Hp-negative group(83 cases)according to Hp test results.General data and carotid plaque status were compared between the two groups.Spearman test was used to analyze the correlation between Hp infection and carotid plaque formation.Multivariate logistic regression analysis was used to analyze the risk factors affecting carotid plaque formation in EH patients.Results The diastolic blood pressure,systolic blood pressure,total cholesterol(TC),triglyceride,fasting blood glucose(FBG),C-reactive protein(CRP)and homocysteine(Hcy)in Hp-positive group were significantly higher than those in Hp-negative group(all P<0.05).The proportion of carotid plaque formation and grade 3 plaque,Crouse score and total plaque load were significantly higher in Hp-positive group than those in Hp-negative group(all P<0.05).Spearman analysis showed that Hp infection was positively correlated with plaque formation(r_(s)=0.292)and Crouse score(r_(s)=0.234)(all P<0.05).Multivatiate logistic regression analysis showed that TC,FBG,CRP and Hcy were independent risk factors for carotid plaque formation in Hp-positive EH patients(all P<0.05).Conclusion There is a weaker correlation between HP infection and carotid plaque in EH patients.

关 键 词：原发性高血压 颈动脉斑块 幽门螺杆菌 空腹血糖 同型半胱氨酸 

分 类 号：R544.1[医药卫生—心血管疾病]