喜炎平注射液联合甲泼尼龙治疗儿童大叶性肺炎的疗效及对炎症反应的影响  

Efficacy of Xiyanping injection combined with methylprednisolone in the treatment of lobar pneumonia in children and its impact on inflammatory responses

作　　者：汪佩林 严仍林 WANG Peilin;YAN Renglin(Department of Pediatrics,Hefei Second People's Hospital,Hefei 230011,China)

机构地区：[1]安徽省合肥市第二人民医院儿科,合肥230011

出　　处：《中国临床药学杂志》2025年第2期128-132,共5页Chinese Journal of Clinical Pharmacy

基　　金：安徽省自然科学基金项目(编号2108086MH260)。

摘　　要：目的探讨喜炎平注射液联合甲泼尼龙治疗儿童大叶性肺炎的疗效及对炎症反应的影响。方法选择2019年10月至2023年10月期间医院收治的儿童大叶性肺炎患者80例,随机分为对照组和观察组,每组40例。对照组患儿给予甲泼尼龙治疗,观察组患儿在甲泼尼龙治疗的基础上给予喜炎平注射液治疗。比较2组患儿的发热消失时间,啰音消失时间,咳嗽缓解时间,肺部阴影吸收时间,住院时间,肺功能指标[用力肺活量(FVC)、最大呼气流量(MEF)、第1秒用力呼气量(FEV_(1))],炎性因子[血清白介素-10(IL-10)、白介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生情况。评估2组患儿治疗后的临床疗效。结果观察组的总有效率高于对照组(97.50%vs 85.00%,P<0.05)。观察组患儿的发热消失时间、啰音消失时间、咳嗽缓解时间、肺部阴影吸收时间及住院时间均短于对照组(P<0.05)。治疗后,2组患儿的FVC、MEF及FEV_(1)水平较治疗前提高,且观察组均高于对照组(P<0.05);2组患儿的血清IL-10、IL-8及TNF-α水平较治疗前降低,且观察组低于对照组(P<0.05)。治疗期间,观察组不良反应总发生率低于对照组(5.00%vs 22.50%,P<0.05)。结论喜炎平注射液联合甲泼尼龙治疗儿童大叶性肺炎疗效确切,能够快速缓解临床症状,改善肺功能,有效抑制炎症反应,降低不良反应发生率,值得临床推广及应用。AIM To investigate the efficacy of Xiyanping injection combined with methylprednisolone in the treatment of lobar pneumonia in children and its impact on inflammatory responses.METHODS A total of 80children with lobar pneumonia treated in the hospital from July 2019 to April 2023 were randomly divided into control group and observation group,with 40 patients in each group.Children with lobar pneumonia in the control group were treated with methylprednisolone,while those in the observation group were treated with Xiyanping injection in addition to methylprednisolone.The fever disappearance time,rale disappearance time,cough relief time,lung shadow absorption time,hospital stay,lung function[forced lung capacity(FVC),maximum expiratory flow(MEF),and forced expiratory volume in the first second(FEV_(1))],inflammatory cytokines[interleukin 10(IL-10),interleukin 8(IL-8),and tumor necrosis factor-alpha(TNF-α)]and adverse reactions were compared between 2 groups of children with lobular pneumonia.The clinical efficacy after treatment in both groups was assessed.RESULTS The observation group demonstrated a significantly higher overall efficacy rate than the control group(97.50%vs 85.00%,P<0.05).The fever disappearance time,rale disappearance time,cough relief time,lung shadow absorption time and hospital stay of children with lobular pneumonia in the observation group were lower than those in the control group(P<0.05).After treatment,FVC,MEF and FEV_(1)levels in children with lobar pneumonia increased in both groups compared to prior treatment,and these levels in the observation group were higher than in the control group(P<0.05).After treatment,the serum levels of IL-10,IL-8 and TNF-αin children with lobar pneumonia in 2 groups were lower than prior treatment,and these levels in the observation group were lower than in those the control group(P<0.05).The incidence of adverse reactions such as dizziness,nausea,vomiting and loss of appetite in the observation group was lower than that in the control group(5.00%vs 22.50%

关 键 词：喜炎平注射液 甲泼尼龙 儿童大叶性肺炎 肺功能 炎症反应 

分 类 号：R285.6[医药卫生—中药学]