莫沙必利联合复方嗜酸乳杆菌片对慢性功能性便秘患者肛肠压力及血清生长抑素水平的影响  

Impacts of mosapride combined with compound Lactobacillus acidophilus tablets on anal pressure and serum somatostatin level in patients with chronic functional constipation

作　　者：刘桂伟[1] 任维聃[1] 杨立胜 姜国胜[1] LIU Guiwei;REN Weidan;YANG Lisheng;JIANG Guosheng(Department of Colorectal and Anal Surgery,Cangzhou Central Hospital,Cangzhou 061000,China)

机构地区：[1]河北省沧州市中心医院结直肠肛门外科,沧州061000

出　　处：《中国临床药学杂志》2025年第2期133-137,共5页Chinese Journal of Clinical Pharmacy

基　　金：河北省2021年度医学科学研究课题计划(编号20210759)。

摘　　要：目的探讨莫沙必利联合复方嗜酸乳杆菌片对慢性功能性便秘患者肛肠压力及血清生长抑素水平的影响。方法将87例慢性功能性便秘患者随机分为单药组(n=44)和联合组(n=43),其中单药组脱落4例,联合组脱落3例,最终2组各有40例患者纳入分析。单药组采用莫沙必利单独治疗,联合组在单药组基础上加用复方嗜酸乳杆菌片治疗。比较2组患者治疗前后肛肠压力及血清生长抑素水平,并评估2组临床疗效。结果经过治疗,联合组总有效率较单药组明显提高(70.00%vs 47.50%,P<0.05);联合组便秘相关症状评分较单药组降低(P<0.05);肛管静息压(ARP)、肛管最大收缩压(AMCP)、肛管最长收缩时间(ALCT)、直肠感觉阈值、排便阈值及直肠顺应性较单药组更降低(P<0.05);血清胃泌素(GAS)、胃动素(MTL)水平高于单药组(P<0.05),生长抑素水平低于单药组(P<0.05)。结论在治疗慢性功能性便秘时,联合应用莫沙必利与复方嗜酸乳杆菌片可显著增强治疗效果,有效降低肛肠压力,并改善胃肠激素水平。AIM To explore the impacts of mosapride combined with compound Lactobacillus acidophilus tablets on anal pressure and serum somatostatin level in patients with chronic functional constipation.METHODS A total of 87patients with chronic functional constipation were randomly separated into monotherapy group(n=44)and combination group(n=43).After 4 dropouts in the monotherapy group and 3 dropouts in the combination group,40 patients in each group were ultimately included in the analysis.The monotherapy group was treated with mosapride alone,while the combination group was treated with compound Lactobacillus acidophilus tablets in addition to the monotherapy group.The anal pressure and serum somatostatin levels before and after treatment were compared between 2 groups,and the clinical efficacy of both groups was evaluated.RESULTS After corresponding treatment,the total effective rate of the combination group was greatly higher than that of the monotherapy group(70.00%vs 47.50%,P<0.05).The constipation-related symptoms score in the combination group was lower than in the monotherapy group(P<0.05).The anal resting pressure(ARP),anal maximal contraction pressure(AMCP),anal longest contraction time(ALCT),rectal sensory threshold,defecation threshold and rectal compliance were lower than those in the monotherapy group(P<0.05).The levels of serum gastrin(GAS)and motilin(MTL)were higher than those in the monotherapy group(P<0.05),while the level of somatostatin was lower than that in the monotherapy group(P<0.05).CONCLUSION For treating chronic functional constipation,using compound Lactobacillus acidophilus tablets combined with mosapride can improve efficacy,reduce anal pressure,and improve gastrointestinal hormone levels.

关 键 词：慢性功能性便秘 莫沙必利 复方嗜酸乳杆菌片 肛肠压力 生长抑素 

分 类 号：R975[医药卫生—药品] R574.4[医药卫生—药学]