生物样本中利奈唑胺浓度测定方法及在治疗药物监测中应用的研究进展  

Research progress on determination methods of linezolid concentration in biological samples and its application in therapeutic drug monitoring

作　　者：刘瑾瑶 李文艳[2] 董婧[2] LIU Jinyao;LI Wenyan;DONG Jing(Postgraduate Training base of Shanghai Gongli Hospital,Ningxia Medical University,Shanghai 200135,China;Department of Pharmacy,Gongli Hospital of Pudong New Area in Shanghai,Shanghai 200135,China)

机构地区：[1]上海市浦东新区公利医院研究生培养基地,宁夏医科大学,上海200135 [2]上海市浦东新区公利医院药学部,上海200135

出　　处：《中国临床药学杂志》2025年第2期154-160,共7页Chinese Journal of Clinical Pharmacy

基　　金：上海市卫生健康委员会科研项目(编号202240349);浦东新区卫生健康委员会学科建设(编号PWZxk2022-26)。

摘　　要：噁唑烷酮类抗菌药物利奈唑胺在对抗多重耐药的革兰阳性菌方面表现出显著的抗菌效果,但其使用可能伴随血小板减少等不良反应。为了优化利奈唑胺的治疗效果并确保用药安全,实施治疗药物监测显得尤为重要。本综述通过系统检索中英文数据库(CNKI和PubMed)并综述相关文献,发现目前有多种方法可用于测定生物样本中的利奈唑胺浓度,包括高效液相色谱法、超高效液相色谱法、免疫分析法、电化学分析法、紫外-分光光度法及伏安法等。在这些方法中,高效液相色谱-紫外检测器法因其操作简便和结果准确而被广泛应用于利奈唑胺的治疗药物监测。然而,该方法存在样本需求量大、分析时间较长等局限性,这促使科研人员探索更为高效和快速的检测技术,以满足临床和实验室的需求。未来,开发新型、快速的测定方法是提升利奈唑胺治疗监测效率的关键。Linezolid,an oxazolidinone antimicrobial agent,has good antibacterial activity against multidrugresistant Gram-positive bacteria but may cause adverse reactions such as thrombocytopenia.To improve the efficacy and ensure the safety of linezolid,therapeutic drug monitoring should be performed.By searching the CNKI database and PubMed database and reviewing relevant literature,we find that there are many methods for the determination of linezolid concentration in biological samples,including high-performance liquid chromatography,ultra-performance liquid chromatography,immunoassay,electrochemical analysis,ultraviolet spectro-photometry,and voltammetry.Highperformance liquid chromatography-ultraviolet absorption detector is convenient,accurate,and widely used in linezolid therapeutic drug monitoring.However,the need for a large volume of biological samples and the complicated pretreatment process associated with this method highlight the necessity for more new and rapid determination methods.The development of novel and rapid determination methods will be crucial for enhancing the efficiency of linezolid therapeutic drug monitoring in the future.

关 键 词：利奈唑胺 高效液相色谱 超高效液相色谱 治疗药物监测 

分 类 号：R917[医药卫生—药物分析学] R978.1[医药卫生—药学]