疾病预防控制人员职业倦怠的研究进展  

Advances in role of miR-296 in fibrosis-related diseases

作　　者：王丹蕾 彭紫怡 张娜 方青 鲜敏[2] 邱五七[3] WANG Danlei;PENG Ziyi;ZHANG Na;FANG Qing;XIAN Min;QIU Wuqi(Institute of Medical Information,Peking Union Medical College,Beijing,100730,China;Shenzhen Bao'an District Center for Disease Control and Prevention,Shenzhen,Guangdong 518101,China;Public Health Strategic Intelligence Research Ofice,Institute of Medical Information,Chinese Academy of Medical Sciences,Beijing 100020,China)

机构地区：[1]北京协和医学院医学信息研究所,北京100730 [2]深圳市宝安区疾病预防控制中心,广东深圳518101 [3]中国医学科学院医学信息研究所公共卫生战略情报研究室,北京100020

出　　处：《职业与健康》2025年第3期410-414,共5页Occupation and Health

基　　金：深圳市卫生经济学会科研基金(202393);深圳市宝安区医疗卫生科研项目(2022JD119)。

摘　　要：《健康中国2030规划纲要》明确提出实施健康中国战略,卫生工作要从“以治病为中心”转变为“以健康为中心”,强调公共卫生服务的重要性,而疾病预防控制(疾控)人员是公共卫生任务的主要实施者和责任人。作为疫情防控与公共卫生安全的“守门人”,疾控人员承担着更大的健康责任与工作压力,成为职业倦怠的高发群体。职业倦怠不仅损害疾控人员的身心健康,而且会对社会造成不良影响。本文查阅相关文献资料,从职业倦怠定义、评估工具、国内外研究现状等方面对疾控人员的职业倦怠情况进行综述,从个人、机构、社会3个层面探讨影响疾控人员职业倦怠的因素并提出相应改善措施,为稳定防控人才队伍和加强公共卫生人才队伍建设提供参考。The fibrosis is an excessive repair response of the organism,which can lead to a variety of tissue and organ dysfunctions manifested by fibroblast activation,proliferation and excessive deposition of extracellular matrix.The microRNA(miRNA)is not only directly involved in the process of multi-organ fibrosis,but also the expression level is affected by the degree of fibrosis,which is a key regulatory factor.In recent years,miR-296 has been found to be dysregulated in fibrosis-related diseases,targets genes involved in fibrosis signaling pathways such as TGF-βand JAK2/STAT3,inflammatory response,cell apoptosis,autophagy,collagen synthesis,and capillary injury through targeted regulation,fibroblast proliferation,epithelial mesenchymal transition,synthesis and degradation of extracellular matrix,and regulates fibrosis process.The paper reviews the mechanism of miR-296's involvement in fibrosis-associated diseases and its potential in the diagnosis and treatment of fibrosis-associated diseases.

关 键 词：疾控人员 职业倦怠 研究进展 

分 类 号：R181.31[医药卫生—流行病学]