生长抑素应用于急性胰腺炎的病理生理机制及应用现状的研究进展  

Research progress on pathophysiological mechanism,physiological mechanism application status of somatostatin in acute pancreatitis

作　　者：孟令宽 陈东风 曹艳(综述) 刘凯军(审校) MENG Lingkuan;CHEN Dongfeng;CAO Yan;LIU Kaijun(Department of Gastroenterology,Daping Hospital,Army Military Medical University,Chongqing 400042,China;Department of Medical Engineering,Daping Hospital,Army Military Medical University,Chongqing 400042,China)

机构地区：[1]陆军军医大学大坪医院消化内科,重庆400042 [2]陆军军医大学大坪医院医学工程科,重庆400042

出　　处：《检验医学与临床》2025年第8期1143-1147,共5页Laboratory Medicine and Clinic

基　　金：重庆市自然科学基金面上项目(cstc2020jcyj-msxm X1100)。

摘　　要：生长抑素(SST)在人类机体内广泛表达并发挥多种生理作用,因其独特的生理作用在临床急性胰腺炎(AP)的救治中得到广泛关注与应用。科学、合理、规范的SST应用是救治AP的关键临床策略。目前SST的应用是AP的常规临床治疗方案,但其应用的科学、合理规范性及具体作用机制未得到广大临床医务工作者的重视。该综述深入分析了SST在AP救治过程中的药理及生理作用机制及最佳给药时机、最优给药剂量、最优持续作用时间等问题,为临床救治提供了理论指导及实践规范,对提高广大医务工作者业务水平以及患者的生活质量具有积极的临床意义。Somatostatin(SST)is widely expressed in human body and plays a variety of physiological effects.Because of its unique physiological effects,it has been widely concerned and applied in the clinical treatment of acute pancreatitis(AP).Scientific,reasonable and normative SST application is the key to the treatment of AP clinical strategies.At present,the application of SST is the routine clinical treatment of AP solution,but the application of scientific and reasonable normative and specific mechanism has not been the attention of the masses of clinical medical workers.This review provides an in-depth analysis of the pharmacological and physiological mechanism of SST in the treatment of AP,as well as the optimal timing,dosage and duration of SST administration.This review provides theoretical guidance and practical norms for clinical treatment,and has positive clinical significance for improving the professional level of medical workers and the quality of life of patients.

关 键 词：急性胰腺炎 生长抑素 基础与临床研究 病理机制 生理机制 

分 类 号：R459.7[医药卫生—急诊医学] R576[医药卫生—治疗学]