方剂配伍理论在中成药研发中的数字化应用分析  

Analysis of the Digital Application of Prescription Compatibility theory in the Research and Development of Proprietary Chinese Medicine

作　　者：姜东京 谈如蓝 宋琪琪 张丽[2] JIANG Dongjing;TAN Rulan;SONG Qiqi;ZHANG-Li(Suzhou Vocational Health College,Suzhou,Jiangsu 215000;Nanjing University of Chinese Medicine,Nanjing Jiangsu 21004)

机构地区：[1]苏州卫生职业技术学院,江苏苏州215000 [2]南京中医药大学,江苏南京210046

出　　处：《智慧健康》2025年第3期15-18,共4页Smart Healthcare

基　　金：江苏省高等教育教学改革研究重点课题(课题编号:2021JSJG065);江苏省教育科学“十四五”规划课题《基于OBE理念的高校劳动教育评价体系研究》(课题编号:B/2021/01/07);“十四五”高等教育科学研究规划课题《新时代中医药院校劳动教育课程体系建设研究》(课题编号:YB016)。

摘　　要：目的研究方剂配伍理论在中成药研发中的数字化应用,通过具体案例验证其对研发效率和疗效的提升效果,探索数字化技术在中药现代化中的潜力。方法选取2023年4月—2024年3月的70个中成药研发案例,按照研发方法分为数字化支持组(35例)和传统方法组(35例)。数字化支持组采用基于方剂配伍理论构建的数字化模型,结合数据挖掘与机器学习技术进行药物研发;传统方法组采用常规经验法指导研发。比较两组研发周期、药效预测准确率及临床疗效,总结方剂配伍理论数字化应用的优势。结果数字化支持组平均研发周期显著低于传统方法组(P<0.05);疗效评价中,数字化支持组总有效率高于传统方法组(P<0.05)。此外,数字化模型在提高药效预测准确率方面表现优异(准确率提升至89.34%)。结论方剂配伍理论的数字化应用显著提升中成药研发的效率和疗效,为中药现代化提供新的研究路径和技术支撑。Objective To study the digital application of prescription compatibility theory in the research and development of proprietary Chinese medicine,verify its effect on the improvement of research and development efficiency and efficacy through specific cases,and explore the potential of digital technology in the modernization of traditional Chinese medicine.Methods Seventy research and development cases of PCM from April 2023 to March 2024 were selected and divided into digital support group(35 cases)and traditional method group(35 cases)according to research and development methods.The digital support group adopted the digital model based on the prescription compatibility theory and combined data mining and machine learning technology to conduct drug research and development.The traditional methods group uses conventional empirical methods to guide research and development.By comparing the research and development period,efficacy prediction accuracy and clinical efficacy of the two groups,the advantages of the digital application of prescription compatibility theory were summarized.Results The average research and development period of the digital support group was shortened to 8.65+1.23 months,which was significantly lower than that of the traditional method group(12.47±2.15 months)(P<0.05).In the evaluation of efficacy,the total effective rate of the digital support group was 92.85%,and that of the traditional method group was 82.57%,the difference was statistically significant(P<0.05).In addition,the digital model performed well in improving the accuracy of drug efficacy prediction(accuracy increased to 89.34%).Conclusion The digital application of prescription compatibility theory can significantly improve the efficiency and efficacy of research and development of proprietary Chinese medicine,and provide a new research path and technical support for the modernization of traditional Chinese medicine.

关 键 词：方剂配伍理论 中成药研发 数字化应用 

分 类 号：R283[医药卫生—中药学]