常规抗心衰治疗结合达格列净片治疗老年心衰的有效性及对血流动力学、心电图的影响  

The Effectiveness of Conventional Anti Heart Failure Treatment Combined with Dapagliflozin Tablets in the Treatment of Elderly Heart Failure and its Impact on Hemodynamics and Electrocardiogram

作　　者：徐成 朱从飞[1] XU Cheng;ZHU Congfei(Department of Cardiology,Lianshui County People's Hospital,Lianshui,Jiangsu 223400)

机构地区：[1]涟水县人民医院心内科,江苏涟水223400

出　　处：《智慧健康》2025年第3期100-103,107,共5页Smart Healthcare

摘　　要：目的探讨对老年心衰患者实施常规抗心衰治疗联合达格列净片治疗的临床效果。方法选取本院2020年3月—2024年8月收治的90例老年心衰患者为研究对象,将入组患者按照治疗方式的不同划分为对照组(n=45)和观察组(n=45)。其中,对照组实施常规抗心衰药物治疗,观察组实施常规抗心衰药物治疗联合达格列净片治疗。治疗前后分别对患者实施心脏彩超检查,检测心率(HR)、左室射血分数(LVEF)水平。治疗前后分别计算两组BMI水平。治疗前后分别对患者进行采血,采用试剂盒检测B型脑钠肽(BNP)水平。并在治疗前后对患者进行6分钟步行距离(6-MWD)试验,评估其评估患者运动耐量。结果治疗前,在平均HR、LVEF水平方面差异均不显著(P>0.05);治疗后,观察组平均HR水平显著低于对照组,LVEF水平显著高于对照组,组内对比显示,两组治疗后平均HR水平均显著下降,LVEF水平均显著提升(P<0.05)。两组治疗前平均BMI水平组间差异不显著(P>0.05);治疗后观察组BMI水平显著低于对照组以及本组治疗前(P<0.05);对照组平均BMI水平显著低于本组治疗前(P<0.05)。在BNP检测水平方面,治疗后的组间比较结果显示,观察组明显低于对照组(P<0.05)。治疗前,两组平均6MWD测试结果对比,差异无统计学意义(P>0.05);治疗后观察组6MWD测试结果显著高于对照组以及本组治疗前(P<0.05);对照组平均6MWD测试结果显著高于本组治疗前(P<0.05)。结论对老年心衰患者实施常规抗心衰治疗联合达格列净片治疗可以更好地改善患者的心功能,获得理想的治疗效果。Objective To explore the clinical efficacy of conventional anti heart failure treatment combined with dapagliflozin in elderly patients with heart failure.Methods 90 elderly heart failure patients were observed,all of whom were admitted to our hospital between March 2020 and August 2024.The enrolled patients were divided into different study groups according to their treatment methods,including a control group(n=45)and an observation group(n=45),and were treated with conventional anti heart failure drugs and conventional anti heart failure drugs combined with dapagliflozin tablets,respectively.Perform cardiac ultrasound examination on patients before and after treatment to detect heart rate(HR)and left ventricular ejection fraction(LVEF)levels.Calculate the BMI levels of both groups before and after treatment.Blood samples were collected from patients before and after treatment,and B-type brain natriuretic peptide(BNP)levels were detected using a reagent kit.And conduct a 6-minute walking distance(6-MWD)test on patients before and after treatment to evaluate their exercise tolerance.Results There was no significant difference in the average HR and LVEF levels before treatment,(P>0.05);After treatment,the average HR level of the observation group was significantly lower than that of the control group,and the LVEF level was significantly higher than that of the control group.Intra group comparison showed that the average HR level of both groups decreased significantly after treatment,and the LVEF level increased significantly(both P<0.05).There was no significant difference in the average BMI levels between the two groups before treatment,(P>0.05);After treatment,the BMI level in the observation group was significantly lower than that in the control group and before treatment in this group(both P<0.05);The average BMI level of the control group was significantly lower than that before treatment in this group,(P<0.05)。In terms of BNP detection levels,the inter group comparison after treatment showed that the obser

关 键 词：心衰 老年患者 抗心衰治疗 达格列净片 

分 类 号：R541.6[医药卫生—心血管疾病]