井穴放血疗法基于内质网应激治疗缺血性脑卒中的机制研究进展  

Mechanism of Well Point Bloodletting Therapy in the Treatment of Ischemic Stroke from the Perspective of Endoplasmic Reticulum Stress

作　　者：刘栋梁 付天聪 刘佩东 汪益 李姗姗[1] 张靖宇 陈波[1,3,4] 郭义 陈泽林[1,3,4] LIU Dongliang;FU Tiancong;LIU Peidong;WANG Yi;LI Shanshan;ZHANG Jingyu;CHEN Bo;GUO Yi;CHEN Zelin(Research Center of Experimental Acupuncture Science,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Shenzhen Bao′an Traditional Chinese Medicine Hospital,Shenzhen 518100,China;National Clinical Research Center for Traditional Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;School of Acupuncture&Moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学实验针灸学研究中心,天津301617 [2]深圳市宝安区中医院,深圳518100 [3]国家中医针灸临床医学研究中心,天津300381 [4]天津中医药大学针灸推拿学院,天津301617

出　　处：《世界中医药》2025年第2期309-314,共6页World Chinese Medicine

基　　金：国家重点研发计划项目(2019YFC1712200,2019YFC1712204);深圳市科技创新委员会基础研究面上项目(JCYJ20210324130602006)。

摘　　要：内质网应激(ERS)已成为缺血性脑卒中发生的关键机制。井穴放血是缺血性脑卒中等脑部疾病的特色疗法之一,是脑病靶向治疗方法;其对缺血性脑卒中的治疗作用包括促醒、改善运动功能;调节缺血性脑卒中ERS的机制包括抑制钙超载、拮抗氧化应激、减轻炎症反应级联损伤,但尚无井穴放血直接调控ERS相关重要蛋白和通路的证据,针刺对缺血性脑卒中ERS相关通路蛋白(蛋白激酶RNA样ER激酶、肌醇需求酶1、激活转录因子-6、CCAAT增强子结合蛋白同源蛋白)的调控作用,可为探讨井穴放血调控ERS的机制研究提供参考。Endoplasmic reticulum stress(ERS)has become a key mechanism in the occurrence of ischemic stroke.Well point bloodletting is one of the characteristic therapies for brain diseases such as ischemic stroke and is a targeted treatment method for brain diseases.Its therapeutic effects on ischemic stroke include promoting awakening and improving motor function.The mechanisms by which well point bloodletting regulates ERS in ischemic stroke involve inhibiting calcium overload,counteracting oxidative stress,and alleviating inflammatory cascade damage.However,there is no direct evidence that well point bloodletting regulates ERS-related key proteins and pathways.Acupuncture has been shown to regulate ERS-related pathway proteins in ischemic stroke,including protein kinase RNA-like ER kinase,inositol-requiring enzyme 1,activating transcription factor-6,and CCAAT/enhancer-binding protein homologous protein.These findings provide a reference for exploring the mechanisms by which well point bloodletting regulates ERS.

关 键 词：井穴 缺血性脑卒中 内质网应激 钙超载 氧化应激 炎症反应 未折叠蛋白反应 针刺 

分 类 号：R245[医药卫生—针灸推拿学] R255.2[医药卫生—中医临床基础]