小柴胡汤防治慢性胃炎的研究进展  

Research Progress on Xiaochaihu Decoction in Preventing and Treating Chronic Gastritis

作　　者：邱亿鸿 张龙 宿洪兵 雷红 朱美薇 管庆霞[1] QIU Yihong;ZHANG Long;SU Hongbing;LEI Hong;ZHU Meiwei;GUAN Qingxia(Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040

出　　处：《世界中医药》2025年第2期344-349,353,共7页World Chinese Medicine

基　　金：国家自然科学基金面上项目(81673611);黑龙江自然科学基金联合引导项目(LH2022H085);黑龙江省中医药科研项目(ZHY2022-111)。

摘　　要：慢性胃炎(CG)是临床上最常见的消化系统疾病之一,受多种因素影响,其主要表现为胃黏膜的长期炎症,因其疗程较长、症状痛苦及复发率高等特点,给患者带来极大的身心负担。小柴胡汤是长期应用于临床的经典方剂,始见于张机《伤寒杂病论》,其功效主要为和解少阳、和胃降逆、扶正祛邪。近年来相关临床研究和文献报道显示,小柴胡汤加减或与其他方药联用治疗不同病机和不同病变程度CG,起到协同增效作用;主要通过抗炎杀菌、调节免疫功能、修复黏膜损伤、调节胃肠激素、促胃肠动力等途径发挥治疗作用。Chronic gastritis(CG)is one of the most common digestive system diseases,influenced by multiple factors.It is characterized by prolonged gastric mucosal inflammation,a long disease course,distressing symptoms,and a high recurrence rate,imposing a significant physical and psychological burden on patients.Xiaochaihu Decoction is a classical prescription used in clinical practice for a long time,which is first recorded in ZHANG Zhongjing′s Treatise on Cold Damage and Miscellaneous Diseases(Shang Han Za Bing Lun).Its main functions include harmonizing Shaoyang,regulating the stomach to alleviate counterflow,and strengthening healthy qi while expelling pathogenic factors.In recent years,clinical studies and literature reports have shown that Xiaochaihu Decoction,when modified or combined with other prescriptions,exerts synergistic effects in treating CG of different pathomechanisms and severity levels.Its therapeutic mechanisms primarily involve anti-inflammatory and antibacterial actions,immune regulation,mucosal repair,modulation of gastrointestinal hormones,and promotion of gastrointestinal motility.

关 键 词：小柴胡汤 慢性胃炎 幽门螺杆菌 临床疗效 作用机制 实验研究 药理作用 研究进展 

分 类 号：R285[医药卫生—中药学]