天津市部分新诊断HIV阳性男男性行为者PrEP和nPEP知晓及使用情况分析  

Awareness and uptake of pre-exposure prophylaxis and non-occupational post-exposure prophylaxis among men who have sex with men newly diagnosed with HIV infection in Tianjin

作　　者：费丽萍 赵鹤鹤 王实 郭燕[2] 龚卉[2] 于茂河[2] 杨杰 汤后林[1] 吕繁[1,4] FEI Liping;ZHAO Hehe;WANG Shi;GUO Yan;GONG Hui;YU Maohe;YANG Jie;TANG Houlin;LYU Fan(National Center for HIV/AIDS Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Institute of Sexually Transmitted Disease and AIDS Prevention and Control,Tianjin Center for Disease Control and Prevention,Tianjin 3000ll,China;Tianjin Shenlan Public Health Consultation Centre,Tianjin 3000ll,China;National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Beijing 102206,China)

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心,北京102206 [2]天津市疾病预防控制中心性病艾滋病预防控制所,天津300011 [3]天津深蓝公共卫生咨询中心,天津300011 [4]传染病溯源预警与智能决策全国重点实验室,北京102206

出　　处：《中国艾滋病性病》2025年第3期283-287,共5页Chinese Journal of Aids & STD

摘　　要：目的了解新诊断HIV阳性MSM对PrEP和nPEP的知晓和使用情况。方法以2023年12月至2024年8月天津市部分新诊断HIV阳性MSM为研究对象,通过问卷调查收集研究对象的基本人口学信息、性行为特征及PrEP、nPEP的知晓和使用情况。使用Logistic回归分析新诊断HIV阳性MSM中PrEP和nPEP知晓的影响因素。结果共计纳入研究对象251人,其中83人(33.1%)知晓PrEP,111人(55.8%)知晓nPEP。12人(4.8%)曾使用过PrEP,9人(3.6%)曾使用过nPEP。多因素Logistic回归分析显示,大专及以上文化程度者(PrEP:aOR=3.31,95%CI:1.66~6.83;nPEP:aOR=2.33,95%CI:1.28~4.28)、性伴数≥2(PrEP:aOR=2.29,95%CI:1.14~4.69;nPEP:aOR=2.02,95%CI:1.12~3.68)、既往有HIV检测史(PrEP:aOR=12.26,95%CI:5.62~30.00;nPEP:aOR=3.99,95%CI:2.21~7.36)是PrEP和nPEP知晓的促进因素。此外,同性性向(aOR=2.52,95%CI:1.08~6.31)也是nPEP知晓的促进因素。结论天津市部分新诊断HIV阳性MSM的PrEP和nPEP的知晓和使用情况均较低。可以通过网络平台、社会组织及同伴教育者在动员MSM进行HIV检测的同时普及PrEP和nPEP知识。Objective This study aimed to investigate awareness and uptake of pre-exposure prophylaxis(PrEP) and non-occupational post-exposure prophylaxis(nPEP) among newly diagnosed HIV-positive men who have sex with men(MSM). Methods The participants were newly diagnosed HIV-positive MSM between December 2023 and August 2024in Tianjin. Data on the participants' demographic characteristics, sexual behaviors, and awareness and uptake of PrEP and nPEP were collected through a questionnaire survey. Logistic regression analysis was used to identify the factors influencing PrEP and nPEP awareness among newly diagnosed HIV-positive MSM. Results A total of 251 participants were included, of whom 83(33.1%) were aware of PrEP and 111(55.8%) were aware of nPEP. Twelve participants(4.8%)had previously used PrEP, while nine participants(3.6%) had used nPEP. Multivariate logistic regression analysis indicated that attainment of college degree or above(for PrEP: aOR=3.31, 95%CI: 1.66-6.83;for nPEP: a OR=2.33,95%CI: 1.28-4.28), having two or more sexual partners(for PrEP: aOR=2.29, 95%CI: 1.14-4.69;for nPEP: aOR=2.02,95%CI: 1.12-3.68), and having a history of HIV testing(for PrEP: aOR=12.26, 95%CI: 5.62-30.00;for nPEP: aOR=3.99,95%CI: 2.21-7.36) were positive predictors of awareness regarding both PrEP and nPEP. Furthermore, homosexual orientation(aOR=2.52, 95%CI: 1.08-6.31) was identified as a positive predictor of nPEP awareness. Conclusions The awareness of PrEP and nPEP among newly diagnosed HIV-positive MSM is relatively low in Tianjin. Knowledge about PrEP and nPEP can be disseminated through online platforms, social organizations, and peer educators, while encouraging the MSM population to undergo HIV testing.

关 键 词：艾滋病病毒感染者 暴露前预防 非职业暴露后预防 知晓 男男性行为者 

分 类 号：R512.91[医药卫生—内科学]