慢性乙型肝炎患者HBV-DNA载量及其与肝纤维化和肝功能的关联性分析  

HBV-DNA Load and Its Association Analysis with Liver Fibrosis and Liver Function in Chronic Hepatitis B Patients

作　　者：纵冰清 黄成伟 薛雅惠 陈静 林小明 李丽平 ZONG Bingqing;HUANG Chengwei;XUE Yahui;CHEN Jing;LIN Xiaoming;LI Liping(Department of Medicine,Zhongshan Hospital,Fudan University(Xiamen Branch),Xiamen,Fujian 361015,China;Department of Critical Care Medicine,Zhongshan Hospital,Fudan University(Xiamen Branch),Xiamen,Fujian 361015,China;Shanghai Hongkou District Center for Disease Control and Prevention(Shanghai Hongkou District Health Supervision Institute)General Office,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院厦门医院医务部,福建厦门361015 [2]复旦大学附属中山医院厦门医院危急重症科,福建厦门361015 [3]上海市虹口区疾病预防控制中心(上海市虹口区卫生健康监督所)综合办,上海200032

出　　处：《中国医药指南》2025年第12期25-28,共4页Guide of China Medicine

基　　金：上海市加强公共卫生体系建设三年行动计划(2023—2025年)优青项目(GWVI-11.2-YQ56)。

摘　　要：目的 分析慢性乙型肝炎病毒(HBV)感染者HBV-DNA载量及其与肝纤维化和肝功能的关联性。方法 选取复旦大学附属中山医院厦门医院2017年8月至2022年10月住院部收治的78例慢性乙肝患者为研究对象。采用荧光定量聚合酶链反应法检测纳入对象的血清HBV-DNA载量,HBV-DNA载量≥100 IU/ml划分为研究组,HBV-DNA载量<100 IU/ml划分为对照组,检测两组患者的肝纤维化指标和肝功能指标,对HBV-DNA载量与肝纤维化和肝功能指标的关系进行Spearman相关分析。结果 研究组患者的ALT、AST、TBIL、DBIL、γ-GT、ALP、TBA值高于对照组(P<0.05),PCⅢ、IV-C、LN、HA水平均高于对照组(P<0.05)。Spearman相关分析结果显示,慢性乙型肝炎患者HBV-DNA载量与肝功能指标ALT、AST、TBIL和肝纤维化指标DBIL、PCⅢ、IV-C、LN呈正相关性(P<0.05)。结论 慢性乙型肝炎患者HBV-DNA病毒载量与肝纤维化及其肝功能之间均有着密切关系,有望将其联合使用从而改善对疾病的诊断效能,临床可据此评估肝纤维化进展、病情严重程度。Objective To analyze HBV-DNA load and its relationship with liver fibrosis and liver function in chronic hepatitis B virus(HBV)infected patients.Methods Seventy-eight patients hospitalized with chronic hepatitis B admitted to the inpatient department of Zhongshan Hospital,Fudan University(Xiamen Branch),from August 2017 to October 2022 were selected for the study.The fluorescence quantitative polymerase chain reaction method was used to detect serum HBV-DNA load,and the patients of HBV-DNA load≥100 IU/ml were assigned in the study group,and the patients of HBV-DNA load<100 IU/ml for the control group.Then liver fibrosis indexes and the functional performance indexes,and Spearman correlation analysis was used to analyze the relationship between HBV-DNA loads and hepatic fibrosis and functional performance indicators.Results Patients in the study group had higher values of ALT,AST,TBIL,DBIL,γ-GT,ALP,and TBA than those in the control group(P<0.05),and higher levels of PC III,IV-C,LN,and HA than those in the control group(P<0.05).The results of the Spearman’s correlation analysis revealed that patients with chronic hepatitis B HBV-DNA load were positively correlated with liver function indexes ALT,AST,TBIL,and liver fibrosis indexes DBIL,PCⅢ,IV-C,LN(P<0.05).Conclusions There is a close relationship between HBV-DNA viral load,liver fibrosis,and liver function in patients with chronic hepatitis B.It is expected to improve the diagnostic efficacy of the disease by combining the detection of HBV-DNA viral load and liver fibrosis,and the clinic can evaluate the progress of liver fibrosis and the severity of the disease accordingly.

关 键 词：乙型肝炎病毒 DNA载量 肝纤维化 肝功能 关联性 

分 类 号：R512.62[医药卫生—内科学]