类风湿关节炎患者发生骨质疏松的危险因素分析  

Analysis of Risk Factors for Osteoporosis in Patients with Rheumatoid Arthritis

作　　者：刘晨 武丽君[2] LIU Chen;WU Lijun(Shihezi University School of Medicine,Shihezi 832003,Xinjiang,China;Department of Rheumatology and Immunology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,Xinjiang,China)

机构地区：[1]石河子大学医学院,新疆石河子832003 [2]新疆维吾尔自治区人民医院风湿免疫科,新疆乌鲁木齐830000

出　　处：《医学信息》2025年第8期96-99,共4页Journal of Medical Information

摘　　要：目的 分析类风湿关节炎(RA)合并骨质疏松(OP)的危险因素。方法 选取2020年1月1日-12月31日于新疆维吾尔自治区人民医院风湿免疫科住院的84例发生OP的RA患者为OP组,随机抽取同时间住院未发生OP的84例患者作为非OP组。收集其临床资料进行组间比较,采用多因素Logistic回归分析RA患者发生OP的危险因素。结果 与非OP组相比,OP组年龄更大,病程更长,DAS28(ESR)评分、DAS28(CRP)评分更高,CRP水平、D二聚体水平更高,关节肿胀数、关节压痛数更多(P<0.05)。多因素Logistic回归分析显示高龄和病程长是RA发生OP的危险因素(P<0.001)。结论 高龄,病程较长,DAS28评分较高,CRP水平、D二聚体水平较高,关节肿胀数、关节压痛数较高的RA患者需警惕OP的发生,尤其是高龄和病程较长的RA患者。Objective To analyze the risk factors of rheumatoid arthritis(RA) complicated with osteoporosis(OP).Methods A total of 84 RA patients with OP who were hospitalized in the Department of Rheumatology and Immunology of the People 's Hospital of Xinjiang Uygur Autonomous Region from January 1,to December 31,2020 were selected as the OP group,and 84 patients without OP who were hospitalized at the same time were randomly selected as the non-OP group.The clinical data were collected and compared between groups,and the risk factors of OP in RA patients were analyzed by multivariate Logistic regression.Results Compared with the non-OP group,patients in the OP group was older,the course of disease was longer,the DAS28(ESR) score and DAS28(CRP) score were higher,the CRP level and D-dimer level were higher,and the number of joint swelling and joint tenderness were more(P<0.05).Multivariate Logistic regression analysis showed that advanced age and long course of disease were risk factors for OP in RA(P<0.001).Conclusion RA patients with advanced age,longer course of disease,higher DAS28 score,higher CRP level and D-dimer level,higher number of joint swelling and joint tenderness should be alert to the occurrence of OP,especially RA patients with advanced age and longer course of disease.

关 键 词：类风湿关节炎 骨质疏松 危险因素 

分 类 号：R593.22[医药卫生—内科学]