麝香通心滴丸预防心导管术后造影剂所致急性肾损伤的临床研究  

Clinical Study of Shexiang Tongxin Dropping Pills on Prevention of Contrast-induced Acute Kidney Injury After Cardiac Catheterization

作　　者：谢礼鑫 陈婷 袁永强 XIE Lixin;CHEN Ting;YUAN Yongqiang(Department of Cardiology,Shangyou County People's Hospital,Shangyou 341200,Jiangxi,China)

机构地区：[1]上犹县人民医院心内科,江西上犹341200

出　　处：《医学信息》2025年第8期123-126,共4页Journal of Medical Information

基　　金：江西省中医药管理局科技计划项目(编号:SZYYB20232192)。

摘　　要：目的 研究麝香通心滴丸预防心导管术后造影剂所致急性肾损伤(CI-AKI)的效果。方法 选取2022年1月-2023年11月就诊于我院拟行冠状动脉造影或经皮冠脉介入术的402例患者为研究对象,采用随机数字表法分为对照组和试验组,各组201例。试验组入院当天开始口服麝香通心滴丸,对照组不予以口服麝香通心滴丸,比较两组术后急性肾损伤发生率、肾功能指标、炎症因子指标、肾动脉阻力指数(RRI)、不良心脏事件发生率。结果 试验组CI-AKI发生率(3.48%)低于对照组(16.42%)(P<0.05);两组血肌酐(SCr)、尿素氮(BUN)均高于术前,肾小球滤过率(e GFR)均低于术前,但试验组SCr、BUN均低于对照组,eGFR高于对照组(P<0.05);两组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)均高于术前,但试验组低于对照组(P<0.05);两组RRI均高于术前,但试验组低于对照组(P<0.05);随访3个月,试验组不良心脏事件发生率(1.99%)与对照组(2.99%)比较,差异无统计学意义(P>0.05)。结论 麝香通心滴丸在预防心导管术后造影剂所致CI-AKI中效果确切,可抑制炎症反应,减轻肾损伤,降低CI-AKI发生率。Objective To study the effect of Shexiang Tongxin dropping pills on the prevention of contrast-induced acute kidney injury(CI-AKI)after cardiac catheterization.Methods A total of 402 patients who underwent coronary angiography or percutaneous coronary intervention in our hospital from January 2022 to November 2023 were selected as the research objects.They were divided into control group and experimental group by random number table method,with 201 patients in each group.The experimental group began to take Shexiang Tongxin dropping pills orally on the day of admission,while the control group did not take Shexiang Tongxin dropping pills orally.The incidence of acute kidney injury,renal function index,inflammatory factor index,renal artery resistance index(RRI) and incidence of adverse cardiac events were compared between the two groups.Results The incidence of CI-AKI in the experimental group(3.48%) was lower than that in the control group(16.42%)( P <0.05).The serum creatinine(SCr) and urea nitrogen(BUN) in the two groups were higher than those before operation,and the glomerular filtration rate(eGFR) was lower than that before operation,but the SCr and BUN in the experimental group were lower than those in the control group,and the eGFR was higher than that in the control group(P<0.05).The levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in the two groups were higher than those before operation,but those in the experimental group were lower than the control group( P<0.05).The RRI of the two groups was higher than that before operation,but that of the experimental group was lower than that of the control group( P<0.05).After 3 months of follow-up,there was no significant difference in the incidence of adverse cardiac events between the experimental group(1.99%) and the control group(2.99%)(P >0.05).Conclusion Shexiang Tongxin dropping pills is effective in preventing CI-AKI caused by contrast agent after cardiac catheterization,which can inhibit inflammatory reaction,red

关 键 词：麝香通心滴丸 心导管术 造影剂 CI-AKI 

分 类 号：R541.4[医药卫生—心血管疾病]