血清Anti-TgAb、Anti-TPOAb、TSH水平联合检测对甲状腺癌患者甲状腺全切除术后复发转移预测价值  

Prognostic Value of Serum Anti-TgAb,Anti-TPOAb and TSH Levels in Patients with Thyroid Cancer After Total Thyroidectomy

作　　者：王璐 王玉莹 Wang Lu;Wang Yuying(Department of Laboratory Medicine,Shangqiu Third People’s Hospital,Shangqiu,Henan,476000,China)

机构地区：[1]商丘市第三人民医院检验科,河南商丘476000

出　　处：《黑龙江医学》2025年第7期834-837,共4页Heilongjiang Medical Journal

摘　　要：目的:探讨血清抗甲状腺球蛋白抗体(Anti-TgAb)、抗甲状腺过氧化物酶抗体(Anti-TPOAb)、促甲状腺素(TSH)水平联合检测对甲状腺癌患者甲状腺全切除术后复发转移的预测价值。方法:回顾性分析2021年10月—2023年10月商丘市第三人民医院接受甲状腺全切除术治疗的80例甲状腺癌患者的临床资料,依据术后1年复发转移发生情况分为发生组28例,未发生组52例。比较两组患者术前、术后2个月血清Anti-TgAb、Anti-TPOAb、TSH水平并计算差值;比较两组患者临床资料;logistic回归分析术后复发转移的影响因素;受试者工作特征曲线(ROC)分析术前、术后2个月血清Anti-TgAb、Anti-TPOAb、TSH水平差值对术后复发转移的预测价值。结果:发生组患者术后血清Anti-TgAb、Anti-TPOAb、TSH水平均高于未发生组,且Anti-TgAb、Anti-TPOAb、TSH水平差值(Anti-TgAb_(△2)、Anti-TPOAb_(△2)、TSH_(△2))均低于未发生组,差异均有统计学意义(t=9.985、8.958、7.158,P<0.001);临床分期、淋巴结转移、肿瘤直径为术后复发转移的独立危险因素,Anti-TgAb_(△2)、Anti-TPOAb_(△2)、TSH_(△2)为术后复发转移的独立保护因素,差异有统计学意义(P<0.05);Anti-TgAb_(△2)、Anti-TPOAb_(△2)、TSH_(△2)联合预测术后复发转移的曲线下面积(AUC)大于单项指标预测,差异有统计学意义(P<0.001)。结论:血清Anti-TgAb、Anti-TPOAb、TSH水平对甲状腺癌患者甲状腺全切除术后复发转移具有一定预测价值。Objective:To investigate the predictive value of serum anti-thyroglobulin antibody(Anti-TgAb),anti-thyroid peroxidase antibody(Anti-TPOAb)and thyrotropin(TSH)combined detection in patients with thyroid cancer after total thyroidectomy.Methods:A retrospective study was conducted on 80 thyroid cancer patients who underwent total thyroidectomy in the hospital from October 2021 to October 2023.Based on the occurrence of recurrence and metastasis 1 year after surgery,the patients were divided into two groups:the occurrence group(n=28)and the non-occurrence group(n=52).The levels of serum Anti-TgAb,Anti-TPOAb,and TSH were compared between the two groups before and 2 months after surgery,and the differences were calculated.Clinical data were compared between the two groups.Logistic regression analysis was conducted to identify the factors affecting postoperative recurrence and metastasis.Receiver operating characteristic(ROC)analysis was used to evaluate the predictive value of the differences in preoperative and postoperative 2-month serum Anti-TgAb,Anti-TPOAb,and TSH levels for postoperative recurrence and metastasis.Results:The levels of serum Anti-TgAb,Anti-TPOAb and TSH in the post-operative group with the occurrence of group were higher than those in the non-occurrence group,and Anti-TgAb,Anti-TPOAb,TSH,Anti-TgAb_(△2),Anti-TPOAb_(△2) and TSH_(△2) were lower than those in the non-occurrence group(t=9.985,8.958,7.158;P<0.001).Clinical stage,lymph node metastasis and tumor diameter were independent risk factors for postoperative recurrence and metastasis,while Anti-TgAb_(△2) Anti-TPOAb_(△2) and TSH_(△2) were independent protective factors for postoperative recurrence and metastasis(P<0.05).The AUC of the combined prediction of Anti-TgAb_(△2),Anti-TPOAb_(△2) and TSH_(△2) for postoperative recurrence and metastasis was greater than that of individual indicators(P<0.001).Conclusion:Serum Anti-TgAb,Anti-TPOAb and TSH levels can predict the recurrence and metastasis of patients with thyroid cancer after

关 键 词：甲状腺癌 抗甲状腺球蛋白抗体 抗甲状腺过氧化物酶抗体 促甲状腺素 

分 类 号：R322.51[医药卫生—人体解剖和组织胚胎学]