硝苯地平联合硫酸镁治疗早产胎膜早破疗效  

Efficacy of nifedipine combined with magnesium sulfate for treating pregnant women with premature rupture of membranes

作　　者：杨坤[1] 刘艳会 郭云霞 YANG Kun;LIU Yanhuil;GUO Yunxia(Liaocheng Second People's Hospital(Liaocheng Second Hospital Affiliated to Shandong First Medical University),Liaocheng,Shandong Province,252600)

机构地区：[1]山东省聊城市第二人民医院,山东第一医科大学附属聊城二院,252600

出　　处：《中国计划生育学杂志》2025年第4期770-774,共5页Chinese Journal of Family Planning

摘　　要：目的:探究硝苯地平联合硫酸镁应用治疗早产胎膜早破临床疗效。方法:选取2021年6月-2024年6月在本院接受治疗的96例早产胎膜早破患者,随机数字表法分为单药组(48例,硫酸镁治疗)和联合组(48例,硝苯地平和硫酸镁联合治疗),对两组临床指标、分娩状况、炎症因子和性激素水平进行对比。记录两组治疗期间出现不良反应情况。结果:治疗后,联合组临床疗效(93.8%)优于单药组(75.0%),治疗时间(4.01±1.13d)、孕<34周分娩率(4.2%)低于单药组(6.21±1.38d、20.8%),孕龄延长时间(8.67±3.45d)、阴道分娩率(75.0%)及新生儿体质量(2.31±0.55kg)高于单药组(6.25±3.21d、35.4%、2.07±0.51kg);两组血清卵泡刺激素、雌二醇、白细胞介素-2、肿瘤坏死因子-α以及干扰素-γ水平均低于治疗前,孕酮水平高于治疗前,且联合组变化幅度高于单药组(均P<0.05)。治疗过程中不良反应发生率联合组(8.3%)与单药组(12.5%)无差异(P>0.05)。结论:硝苯地平联合硫酸镁治疗早产胎膜早破提高了临床疗效,减少治疗周期和宫缩抑制时间,延长妊娠时间,改善患者炎症标志物和性激素水平,不良反应发生率低。Objective:To investigate the efficacy and the pharmacy safety of nifedipine combined with magnesium sulfate for treating pregnant women with premature rupture of membranes(PRM).Methods:From June 2021 to June 2024,96 pregnant women with PRM who received treatment in the hospital were included and were divided into control group(48 cases with the treatment of magnesium sulfate)and study group(48 cases with the treatment of nifedipine combined with magnesium sulfate)according to the random number table method.The clinical indicators,the delivery status,and the levels of the inflammatory factors and sex hormone of the women were compared between the two groups.And the adverse reactions of the women in both groups during the treatment period were recorded.Results:After treatment,the clinical efficacy(93.8%)of the women in the study group was significantly better than that(75.0%)of the women in the control group.The treatment duration(4.01±1.13d)and the delivery rate in<34 gestational weeks(4.2%)of the women in the study group were significantly lower than those(6.21±1.38d and 20.8%)of the women in the control group.The prolonged time of gestational weeks(8.67±3.45d),the vaginal delivery rate(75.0%)and the neonatal weight(2.31±0.55kg)of the women in the study group were significantly higher than those(6.25±3.21d,35.4%and 2.07±0.51kg)of the women in the control group.The levels of the serum follicle-stimulating hormone,estradiol,interleukin-2,tumor necrosis factor-αand interferon-γof the women in the two groups after treatment had decreased significantly,and the progesterone level of the women in the two groups after treatment had decreased significantly,and the all changes of which of the women in the study group were significantly more than those of the women in the control group(all P<0.05).There was no significant difference in the incidence of the adverse reactions(8.3%vs.12.5%)of the women between the two groups(P>0.05).Conclusion:Nifedipine combined with magnesium sulfate for treating the pregnant women w

关 键 词：早产胎膜早破 硝苯地平 硫酸镁 临床疗效 

分 类 号：R714.21[医药卫生—妇产科学]