瑞马唑仑复合舒芬太尼对无痛人工流产女性炎症反应及疼痛介质的影响  

Effects of remazolam combined with sufentanil used in women during painless abortion on their inflammation and pain mediators

作　　者：刘敏[1] 余艳萍 陈仁军 唐银萍 吴艳[1] LIU Min;YU Yanping;CHEN Renjun;TANG Yinping;WU Yan(Chuzhou Hospital Affiliated to Anhui Medical University(Chuzhou First People's Hospital),Chuzhou,Anhui Province,239000)

机构地区：[1]安徽医科大学附属滁州医院,滁州市第一人民医院,239000

出　　处：《中国计划生育学杂志》2025年第4期781-785,共5页Chinese Journal of Family Planning

摘　　要：目的:探究无痛人工流产术麻醉采用瑞马唑仑复合舒芬太尼对受术者炎症反应及疼痛介质影响。方法:纳入本院2022年4月-2024年4月收治的自愿要求行无痛人工流产女性152例,按照随机信封法分为两组各76例,对照组给予丙泊酚联合舒芬太尼麻醉,观察组给予瑞马唑仑联合舒芬太尼麻醉,比较两组手术相关指标,麻醉效果,治疗前后炎症指标、疼痛介质及疼痛感受,不良反应发生率。结果:观察组意识恢复时间、麻醉用药追加次数、手术出血量、定向力恢复时间均低于对照组,麻醉有效率(97.4%)高于对照组(88.2%)(P<0.05);术后观察组白细胞介素-6(18.84±3.25 pg/ml)、高迁移率族蛋白(B151.84±11.27μg/L)、肿瘤坏死因子α(13.18±3.56 pg/ml)水平均低于对照组(23.16±3.68 pg/ml、63.29±12.54μg/L、16.51±3.84 pg/ml),P物质(1.46±0.37μg/ml)、前列腺素(172.75±19.84 pg/ml)、去甲肾上腺素(2.86±0.76 pg/ml)以及皮质醇(25.32±4.32μg/ml)等疼痛介质水平与视觉模拟评分(2.15±0.53分)均低于对照组(1.89±0.47μg/ml、203.54±22.53 pg/ml、3.49±0.85 pg/ml、32.75±4.54μg/ml、3.11±0.92分),不良反应发生率(6.6%)低于对照组(17.1%)(均P<0.05)。结论:无痛人工流产麻醉应用瑞马唑仑复合舒芬太尼有助于减轻受术女性体内炎症反应,抑制疼痛介质释放,降低不良反应发生。Objective:To investigate the impact of remazolam combined with sufentanil used in women during painless abortion on their inflammation and pain mediators.Methods:A total of 152 pregnant women who wanted painless abortion admitted to the hospital were selected and were divided into control group(76 women with propofol combined with sufentanil used in painless abortion)and the observation group(76 women with sufentanil combined with remazolam used in painless abortion)by random envelope method from April 2022 to April 2024.The related surgical indicators values,the anesthetic effect,and the inflammatory indicators values,the pain mediators levels,the pain perception before and after treatment and the adverse reactions rate of the women were compared between the two groups.Results:The time of consciousness recovery,the additional times of anesthesia medication,the intraoperative blood loss and the recovery time of orientation of the women in the observation group were significantly lower than those of the women in the control group.The effective rate of anesthesia(97.4%)of the women in the observation group was significantly higher than that(88.2%)of the women in the control group(P<0.05).The levels of interleukin-6(18.84±3.25 pg/ml),high mobility group protein B(151.84±11.27μg/L)and tumor necrosis factor-α(13.18±3.56 pg/ml)of the women in the observation group were significantly lower than those(23.16±3.68 pg/ml,63.29±12.54μg/L and 16.51±3.84 pg/ml)of the women in the control group.The levels of the pain mediators,such as substance P(1.46±0.37μg/ml),prostaglandin(172.75±19.84pg/ml),norepinephrine(2.86±0.76pg/ml)and cortisol(25.32±4.32μg/ml),and the visual analogue scale(VAS)score(2.15±0.53points)of the women in the observation group were significantly lower than those(1.89±0.47μg/ml,203.54±22.53pg/ml,3.49±0.85pg/ml,32.75±4.54μg/ml and 3.11±0.92points)of the women in the control group.The incidence of the adverse reactions(6.6%)of the women in the observation group was significantly lower than

关 键 词：无痛人工流产术 瑞马唑仑 舒芬太尼 麻醉 镇痛 炎症反应 疼痛介质 

分 类 号：R614[医药卫生—麻醉学]