布比卡因脂质体与罗哌卡因用于剖宫产术后腹横肌平面阻滞镇痛效果比较  

Comparison of the analgesic effect of bupivacaine liposomes and ropivacaine used in transversus abdominis plane block for analgesia of women after cesarean section

作　　者：张淑媛 王海丽 潘华 ZHANG Shuyuan;WANG Haili;PAN Hua(College of Clinical Medicine,The First Affiliated Hospital,of Henan University of Science and Technology,Luoyang,Henan Province,471003;Sanmenaia Central Hospital Affiliated to Henan University of Science and Technology)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院,洛阳471003 [2]河南科技大学附属三门峡市中心医院

出　　处：《中国计划生育学杂志》2025年第4期805-809,共5页Chinese Journal of Family Planning

摘　　要：目的:研究布比卡因脂质体和罗哌卡因用于剖宫产术后腹横肌平面阻滞(TAPB)镇痛的临床效果比较。方法:选取2023年12月-2024年4月三门峡市中心医院行剖宫产术的产妇60例,按随机数表法分为LRP组[罗哌卡因行TAPB复合患者自控静脉镇痛(PCIA)]和LBP组(布比卡因脂质体行TAPB复合PCIA)各30例,比较两组围术期相关指标,术后不良反应发生率、术后疼痛、舒芬太尼用量、病房恢复指标。结果:LBP组不良反应发生率(10.0%)低于LRP组(40.0%)。镇痛相关指标术后6h、12h、24h、48h、72h的静息和咳嗽时VAS评分均低于LRP组,镇痛泵按压数(3.53±1.17次)少于LRP组(13.0±3.47次),镇痛药物-舒芬太尼48h使用量(77.47±6.71μg)少于LRP组(98.63±2.65μg),术后首次进食流质食物时间、第一次排气、第一次下床、第一次独立活动时间均早于LRP组,术后24h、48h、72h的术后恢复质量QoR-40量表评分(115.63±9.02分、136.93±9.18分、172.6±7.34分)均高于LRP组(均P<0.05)。结论:与使用罗哌卡因行TAPB复合PCIA这种传统镇痛方式相比,布比卡因脂质体应用于剖宫产术后TAPB复合PCIA可以减少不良反应发生率,有效减轻术后疼痛,减少舒芬太尼的使用量,有利于产妇更早活动,利于产妇康复。Objective:To compare the clinical efficacy of bupivacaine liposomes and ropivacaine used in transversus abdominis plane block(TAPB)for analgesia of women after cesarean section.Methods:60 pregnant women who wanted cesarean sections in Sanmenxia central hospital were selected and were randomly divided into two groups from December 2023 to April 2024.30 women in the control group received ropivacaine for TAPB combined with patient-controlled intravenous analgesia(PCIA),while 30 women in the experimental group received bupivacaine liposomes for TAPB combined with PCIA.The values of the perioperative related indicators,the incidence of postoperative adverse reactions,the postoperative pain situation,the dosage of sufentanil used and the ward recovery indicators of the women were compared between the two groups.Results:The incidence of the adverse reactions(10.0%)of the women in the experimental group was significantly lower than that(40.0%)of the women in the control group.The VAS scores of the women at rest and at cough in the experimental group at 6h,12h,24h,48h and 72h after operation were significantly lower than those of the women in the control group.The number of analgesic pump pressing(3.53±1.17 times)of the women in the experimental group was significantly less than that(13.0±3.47 times)of the women in the control group.The dosage of sufentanil used(77.47±6.71μg)of the women in the experimental group at 48h after operation was significantly less than that(98.63±2.65μg)of the women in the control group.The time of the first liquid food intake,the first exhaust time,the time of getting out of bed firstly and the first independent activity time of the women in the experimental group were significantly earlier than those of the women in the control group.The QoR-40scores of the women in the experimental group at 24h,48hand 72hafter operation(115.63±9.02points,136.93±9.18points and 172.6±7.34points)were significantly higher than those of the women in the control group(all P<0.05).Conclusion:Compared with

关 键 词：剖宫产术 术后镇痛 布比卡因脂质体 腹横肌平面阻滞 

分 类 号：R614[医药卫生—麻醉学]