梅毒感染孕产妇不良妊娠结局危险因素分析  

Analysis of the risk factors of the adverse pregnancy outcomes of pregnant women with syphilis infection

作　　者：肖纯荣[1] 张帅 黎雪彬 高德华 XIAO Chunrong;ZHANG Shuai;LI Xuebin;GAO Dehua(Dechang County People's Hospital,Liangshan,Sichuan Province,615500;The First People's Hospital of Liangshan Yi Autonomous Prefecture,Sichuan Province)

机构地区：[1]四川省德昌县人民医院,615500 [2]四川省凉山彝族自治州第一人民医院

出　　处：《中国计划生育学杂志》2025年第4期891-895,共5页Chinese Journal of Family Planning

摘　　要：目的:分析梅毒感染孕产妇不良妊娠结局发生危险因素。方法:收集2020年7月-2024年7月本院收治的1168例梅毒感染孕产妇临床资料,采用单、多因素分析方法对梅毒感染孕产妇不良妊娠结局影响因素进行分析。结果:1168例中发生25.1%不良妊娠结局,其中自然流产30例(2.6%),死胎或死产18例(1.5%),1周内死亡10例(0.9%),早产或低出生体重165例(14.1%),新生儿窒息16例(1.4%),新生儿肺炎12例(1.0%),发生出生缺陷22例(1.9%),新生儿先天梅毒20例(1.7%)。logistic回归分析,年龄≥35岁(OR=2.973)、初产妇(OR=2.041)、未规范治疗(OR=1.186)、未治疗(OR=3.148)、确诊时梅毒滴度≥1:8(OR=1.843)是梅毒感染孕产妇不良妊娠结局发生的独立危险因素。结论:梅毒感染孕产妇不良妊娠结局发生率较高,年龄≥35岁、初产妇、未规范治疗及未治疗、确诊时梅毒滴度≥1:8是梅毒感染孕产妇不良妊娠结局发生的独立危险因素。Objective:To analyze the risk factors of the adverse pregnancy outcomes of pregnant women with syphilis infection.Methods:The clinical data of 1168 pregnant women with syphilis infection admitted to the hospital from July 2020 to July 2024 were collected.Univariate and multivariate analysis were used to analyze the influencing factors of the adverse pregnancy outcomes of the pregnant women with syphilis infection.Results:Among 1168 pregnant women with syphilis infection,there were 25.1%women with adverse pregnancy outcomes,including 30(2.6%)cases with spontaneous abortion,18(1.5%)cases with stillbirth or stillbirth,10(0.9%)cases with infants death within 1 week after born,165(14.1%)cases with premature delivery or low birth weight,16(1.4%)cases with neonatal asphyxia,12(1.0%)cases with neonatal pneumonia,22(1.9%)cases with birth defects and 20(1.7%)cases with infants congenital syphilis.Logistic regression analysis showed that the age≥35 years old(OR=2.973),the primiparas(OR=2.041),the unregulated treatment(OR=1.186),the no treatment(OR=3.148)and the syphilis antibody titer≥1:8 at diagnosis(OR=1.843)of the pregnant women with syphilis infection were the independent risk factors of their adverse pregnancy outcomes.Conclusion:The incidence of the adverse pregnancy outcomes of the pregnant women with syphilis infection is higher.The age≥35 years old,the primiparas,the unregulated treatment(OR=1.186),the no treatment and the syphilis antibody titer≥1:8 at diagnosis of the pregnant women with syphilis infection are the independent risk factors of their adverse pregnancy outcomes.

关 键 词：孕产妇 梅毒感染 不良妊娠结局 危险因素 

分 类 号：R714.25[医药卫生—妇产科学]