血清sFlt-1/PIGF比值联合彩色多普勒超声诊断胎盘植入价值  

Diagnostic value of the serum soluble vascular endothelial growth factor receptor-1/placental growth factor ratio combined with color Doppler ultrasound for placental accreta

作　　者：侯银玲 蒋静 郝建磊 梁柏松 李荣兴 HOU Yinling;JIANG Jing;HAO Jianlei;LIAMG Baisong;LI Rongxing(Nanjing Pukou People's Hospital,Nanjing,Jiangsu Province,211899;Suzhou Hospital Affiliated to Nanjing Medical University,Jiangsu Province)

机构地区：[1]江苏省南京市浦口人民医院,211899 [2]南京医科大学附属苏州医院

出　　处：《中国计划生育学杂志》2025年第4期930-934,共5页Chinese Journal of Family Planning

基　　金：浦口区社会事业科技发展计划项目(S2022-5)。

摘　　要：目的:探讨血清可溶性血管内皮生长因子受体-1/胎盘生长因子比值(sFlt-1/PIGF)联合彩色多普勒超声诊断胎盘植入价值。方法:根据病理结果将2021年4月-2024月4月本院收治的213例孕妇分为胎盘植入组(n=90)和非胎盘植入组(n=123)。纳入对象入院后均经彩色多普勒超声检查,检测外周血可溶性血管内皮生长因子受体-1(sFlt-1)、胎盘生长因子(PIGF)水平,计算sFlt-1/PIGF比值。比较两组一般资料及sFlt-1/PIGF比值;评价血清sFlt-1/PIGF比值、彩色多普勒超声诊断胎盘植入的效能。结果:胎盘植入组血sFlt-1、sFlt-1/PIGF比值均高于非胎盘植入组,PIGF水平低于非胎盘植入组(均P<0.05)。以病理结果为最终标准,彩色多普勒超声、血清sFlt-1/PIGF比值及2项联合诊断胎盘植入与病理结果诊断一致率分别为80.5%、78.7%、84.5%,诊断胎盘植入的灵敏度分别为72.2%、68.9%、82.2%,漏诊率分别为27.8%、31.1%、17.8%,阴性预测值分别为78.8%、77.2%、84.9%。结论:胎盘植入孕妇血清sFlt-1/PIGF比值异常升高,与彩色多普勒超声联合诊断胎盘植入发生效能提高。Objective:To investigate the diagnostic value of the serum soluble vascular endothelial growth factor receptor-1/placental growth factor(sFlt-1/PIGF)ratio combined with color Doppler ultrasound for placental accreta.Methods:213 pregnant women from April 2021 to April 2024 were selected as the study subjects,and these women were divided into group A(90 women with placental accreta)and group B(123 women without placental accreta)according to the postoperative pathological results.After admission,the women in the two groups were examined by color Doppler ultrasound and were detected their levels of sFlt-1 and PIGF in peripheral blood,and the ratio of sFlt-1/PIGF was calculated.The general data and the sFlt-1/PIGF ratio of the women were compared between the two groups.The efficacy of the serum sFlt-1/PIGF ratio and the color Doppler ultrasound for diagnosing the placental accreta of the women were evaluated.Results:The sFlt-1 level and the sFlt-1/PIGF ratio of the women in group A were significantly higher than those of the women in group B,and the level of PIGF of the women in group A was significantly lower than that of the women in group B(all P<0.05).The pathological results were as the final standard,the consistency rates of the color Doppler ultrasound combined with the serum sFlt-1/PIGF ratio for diagnosing the placenta accreta were 80.5%,78.7%and 84.5%,respectively,the sensitivity of which were 72.2%,68.9%and 82.2%,respectively,the rate of missed diagnosis of which were 27.8%,31.1%and 17.8%,respectively,and the negative predictive value of which were 78.8%,77.2%and 84.9%,respectively.Conclusion:The serum sFlt-1/PIGF ratio of the pregnant women with placenta accreta is abnormally elevated,and the color Doppler ultrasound combined with the serum sFlt-1/PIGF ratio for diagnosing the placenta accreta has higher efficiency.

关 键 词：胎盘植入 可溶性血管内皮生长因子受体-1/胎盘生长因子比值 彩色多普勒超声 诊断价值 

分 类 号：R714.2[医药卫生—妇产科学]