HDP患者血清PLGF、MPV、D-D水平及对妊娠结局的影响  

Levels of the serum placental growth factor,mean platelet volume and D-dimer of pregnant women with hypertensive disorders complicating pregnancy and their influences on the pregnancy outcomes of the women

作　　者：任萍 万永超 赵佳 REN Ping;WAN Yongchao;ZHAO Jia(Nanchong Central Hospital,Nanchong,Sichuan Province,637000)

机构地区：[1]四川省南充市中心医院,637000

出　　处：《中国计划生育学杂志》2025年第4期960-966,共7页Chinese Journal of Family Planning

基　　金：四川省卫生和计划生育委员会科研课题(17PJ200)。

摘　　要：目的:探究妊娠期高血压疾病(HDP)患者血清胎盘生长因子(PLGF)、平均血小板体积(MPV)、D-二聚体(D-D)水平对妊娠结局的影响。方法:收集2021年10月-2023年3月本院妇产科确诊为HDP的孕妇97例临床资料为疾病组,根据血压及尿蛋白水平分为妊娠期高血压组(n=11)、先兆子痫组(n=64)及子痫组(n=22),另收集本院产前检查正常孕妇97例为健康组。比较两组一般资料、实验室指标和妊娠结局,不同类型HDP孕妇PLGF、MPV及D-D水平;多因素logistic回归分析HDP孕妇妊娠结局的影响因素,绘制受试者工作特征(ROC)曲线评估PLGF、MPV、D-D水平对HDP患者妊娠结局的预测效能。结果:疾病组24 h尿蛋白、收缩压、舒张压、MPV、D-D水平高于健康组,PLGF水平低于健康组,且子痫组、先兆子痫组、妊娠期高血压组24 h尿蛋白、收缩压、舒张压、MPV及D-D水平依次升高,PLGF水平依次降低(P<0.05)。HDP患者中子痫组不良妊娠结局发生率最高(18.2%);ROC曲线显示,HDP孕妇PLGF、MPV、D-D预测妊娠结局均有一定价值,且D-D预测效能最高,其曲线下面积为0.932,敏感度76.9%、特异性97.6%;多因素分析,高PLGF为HDP孕妇妊娠结局的保护因素,高MPV、高D-D为HDP孕妇妊娠结局的危险因素(均P<0.05);结论:HDP孕妇血D-D、MPV均异常升高,PLGF异常降低,且与HDP病情和妊娠结局有关,对预测妊娠结局有一定价值。Objective:To explore the influence of the serum placental growth factor(PLGF),mean platelet volume(MPV)and D-dimer(D-D)levels of pregnant women with hypertensive disorders complicating pregnancy(HDCP)on their pregnancy outcomes.Methods:The clinical data of 97 pregnant women diagnosed with HDCP(in study group)in the department of obstetrics and gynecology of the hospital from October 2021 to March 2023 were collected,and these pregnant women were divided into group A(11 cases with gestational hypertension),group B(64 cases with preeclampsia)and group C(22 cases with eclampsia)based on the blood pressure value and the urinary protein level of these women.Another 97 pregnant women without HDCP who received antenatal examination were included in control group during the same period.The general data,the laboratory examination indicators values and the pregnancy outcomes of the women were compared between the study group and the control group.The levels of PLGF,MPV and D-D of the women in the study group were compared among group A,group B and group C.The influencing factors of the pregnancy outcomes of the women with HDCP were analyzed by multivariate logistic regression analysis.Receiver operating characteristic(ROC)curve was drawn to evaluate the predictive efficiency of the PLGF,MPV and D-D levels of the women with HDCP for their pregnancy outcomes.Results:The levels of 24 h urinary protein,MPV and D-D,and the values of the systolic blood pressure and diastolic blood pressure of the women in the study group were significantly higher than those of the women in the control group,and the level of PLGF of the women in the study group was significantly lower than that of the women in the control group.The levels of 24hurinary protein,MPV and D-D,and the values of the systolic blood pressure and diastolic blood pressure of the women in group C,in group B and in group A had increased gradually,and the level of PLGF of the women in group C,in group B and in group A had decreased gradually(P<0.05).The incidence of the adver

关 键 词：妊娠期高血压疾病 胎盘生长因子 平均血小板体积 D-二聚体 妊娠结局 影响因素 预测 

分 类 号：R714.24[医药卫生—妇产科学]