新生儿Ⅲ度羊水胎粪污染的预警因素及与新生儿不良结局关系  

Early warning factors of theⅢdegree meconium-stained of amniotic fluid of the neonates and its correlation with the adverse neonatal outcomes

作　　者：张青 王金娥[1] 王双[1] ZHANG Qing;WANG Jin'e;WANG Shuang(The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu Province,210029)

机构地区：[1]南京医科大学第一附属医院,210029

出　　处：《中国计划生育学杂志》2025年第4期988-992,998,共6页Chinese Journal of Family Planning

摘　　要：目的:分析新生儿Ⅲ度羊水胎粪污染的预警因素及与新生儿不良结局关系。方法:回顾性收集2020年8月-2023年8月于本院分娩的108例产妇临床资料,依据新生儿是否发生Ⅲ度羊水胎粪污染分为无污染组(n=74)、轻度污染组(n=20)和Ⅲ度污染组(n=14)。分析产妇及新生儿临床资料,logistic多因素回归分析影响新生儿Ⅲ度羊水胎粪污染的预警因素;依据新生儿结局分为不良结局组(n=12)和良好结局组(n=96),对比两组预警因素,并采用Spearman相关分析预警因素与新生儿不良结局关系。结果:logistic多因素回归分析显示,产妇年龄≥35岁、妊娠期糖尿病、妊娠高血压疾病、产程延长、羊水过少、存在先兆子痫、胎膜早破、脐带、胎盘异常是新生儿Ⅲ度羊水胎粪污染的独立危险因素;不良结局组产妇年龄≥35岁、妊娠期糖尿病、妊娠高血压疾病、产程延长、羊水过少、先兆子痫占比高于良好结局组(均P<0.05)。相关性分析显示,产妇年龄≥35岁、妊娠期糖尿病、妊娠高血压疾病、产程延长、羊水过少、先兆子痫与新生儿不良结局发生均呈正比(P<0.05)。结论:新生儿Ⅲ度羊水胎粪污染受产妇高龄、妊娠期糖尿病、妊娠高血压疾病、产程延长、羊水过少等因素影响,这些预警因素与新生儿不良结局密切相关,临床应重点筛查上述指标并积极采取防治措施。Objective:To analyze the early warning factors of the III degree meconium-stained of amniotic fluid of the neonates,and to study its correlation with the adverse neonatal outcomes.Methods:The clinical data of 108 women who had delivered in the hospital from August 2020 to August 2023 were analyzed retrospectively.According to whether the neonates with the III-degree meconium-stained of amniotic fluid or not,these women were divided into group A(74 women without the meconium-stained of amniotic fluid),group B(20 women withⅢdegree meconium-stained of amniotic fluid)and group C(14 women with III-degree meconium-stained of amniotic fluid).The clinical data of the women and their neonates in the three groups were analyzed.Logistic multivariate regression analysis was used to analyze the early warning factors of the neonatal meconium-stained of amniotic fluid.According to the neonatal outcomes,these neonates were divided into group D(12 neonates with the poor outcomes)and group E(96 neonates with the good outcomes).The early warning factors the III-degree meconium-stained of amniotic fluid of the neonates were compared between group D and group E.Spearman correlation was used to analyze the correlation between the early warning factors of the meconium-stained of amniotic fluid of the neonates and their adverse neonatal outcomes.Results:Multivariate logistic regression analysis showed that the maternal age≥35 years old,the gestational diabetes mellitus(GDM),the hypertensive disorders complicating pregnancy(HDCP),the prolonged labor,the oligohydramnios,the pre-eclampsia,the premature rupture of membranes,the abnormalities of umbilical cord and placental of the neonates were the independent risk factors of theirⅢdegree meconium-stained of amniotic fluid.The proportions of the maternal age≥35years old,the maternal GDM,the maternal HDCP,the maternal prolonged labor,the oligohydramnios and the maternal pre-eclampsia of the neonates in group D were significantly higher than those of the neonates in group C(all P<0.05)

关 键 词：新生儿 Ⅲ度羊水胎粪污染 预警因素 不良结局 相关性 

分 类 号：R722.1[医药卫生—儿科]