脓毒症生物标志物:过去、现在和未来  

Sepsis biomarkers:past,present,and future

作　　者：何迪 王在[2] 曹彬[3] He Di;Wang Zai;Cao Bin(China-Japan Friendship School of Clinical Medicine,Capital Medical University,Beijing 100029,China;Institute of Clinical Medical Sciences,China-Japan Friendship Hospital,Beijing 100029,China;Center of Respiratory Medicine,China-Japan Friendship Hospital,Institute of Respiratory Medicine,Chinese Academy of Medical Sciences,National Center of Respiratory Medicine,Beijing 100029,China)

机构地区：[1]首都医科大学中日友好临床医学院,北京100029 [2]中日友好医院临床医学研究所,北京100029 [3]中日友好医院呼吸中心,中国医学科学院呼吸病学研究所,国家呼吸医学中心,北京100029

出　　处：《中华微生物学和免疫学杂志》2025年第3期198-204,共7页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(82241056)。

摘　　要：脓毒症是由感染诱发的宿主免疫应答失调引起的急性器官功能障碍综合征,是全球人类健康的重要挑战。尽管多种生物标志物已被发现,其临床转化仍面临困难。本文回顾了脓毒症生物标志物研究的历史沿革,涵盖从早期炎症指标探索到多组学技术与人工智能驱动的精准诊疗新时代,总结了当前标志物在早期诊断、病原体识别和精准治疗中的临床应用现状,并分析了脓毒症病理生理复杂性、真实世界研究不足及标准化评估框架缺失对标志物研究与应用的制约。展望未来,通过动态监测和精准分型等技术手段的深入应用,结合多学科协作研究,将有助于推进标志物的临床转化,助力脓毒症精准诊治的发展。Sepsis,a life-threatening syndrome characterized by acute organ dysfunction due to a dysregulated host response to infection,remains a significant global health challenge.Despite the identification of numerous biomarkers,their clinical translation remains challenging due to various limitations.In this article,we review the historical evolution of sepsis biomarker research,tracing the progression from early inflammatory marker research to the advent of multi-omics technologies and artificial intelligence-driven precision medicine.We summarize the current clinical applications of biomarkers in early diagnosis,pathogen identification,and precision treatment.Furthermore,we discuss key barriers including the complex pathophysiology of sepsis,insufficient real-world studies,and the lack of standardized evaluation frameworks in advancing biomarker research and utilization.Looking ahead,leveraging advanced approaches such as dynamic monitoring and precision stratification,combined with multidisciplinary collaboration,is expected to facilitate biomarker clinical translation and support the development of precision medicine for sepsis.

关 键 词：脓毒症 生物标志物 精准医学 

分 类 号：R459.7[医药卫生—急诊医学]