中性粒细胞胞外诱捕网在脓毒症及其器官功能障碍中的研究进展  

Progress in the role of neutrophil extracellular traps in sepsis and organ dysfunction

作　　者：秦利静 畅智慧[1] Qin Lijing;Chang Zhihui(Department of Radiology,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院放射科,沈阳110004

出　　处：《中华微生物学和免疫学杂志》2025年第3期264-268,共5页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(82272097)。

摘　　要：脓毒症是由于宿主无法限制感染而引起的全身炎症反应综合征,其引发的多器官功能障碍不仅能加重病情,还能导致不良预后,成为全球迫切需要解决的医学问题。中性粒细胞在外周血中参与人体的许多生理和病理过程,是免疫系统抵御病原体感染的第一道防线。此外,中性粒细胞可以在病原体的刺激下,释放一种含有多种蛋白质成分并以DNA为骨架的特殊网状结构,即中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)。虽然NETs可以杀死病原体,但过量的NETs会加重脓毒症,引起多器官功能损伤,包括肺损伤、肾损伤和肝损伤等。本文旨在深入探讨NETs在脓毒症及脓毒症引发的多器官功能障碍中的作用,为治疗脓毒症提供新的研究方向。Sepsis is a clinical syndrome resulting from infection followed by inflammation and is one of the significant causes of mortality worldwide.The underlying reason is the host′s uncontrolled inflammatory response to an infection,which leads to multiple organ dysfunction.It not only aggravates the condition,but also leads to a poor prognosis.Neutrophils are involved in many physiological and pathological processes in the human body and are forerunners to reach the site of infection/inflammation for clearing the infection and resolute the inflammation during sepsis.In addition,under the stimulation of pathogens,neutrophils can release a special network structure containing a variety of protein components and DNA as the skeleton,which is named neutrophil extracellular traps(NETs).Although NETs can kill pathogens,excess NETs have a significant influence on the pathogenesis of sepsis-induced multiple organ damage,including lung,kidney,and liver damage.This review aims to introduce the role of NETs in sepsis and organ dysfunction,hoping to provide new ideas for the treatment of sepsis.

关 键 词：脓毒症 NETS 器官功能障碍 

分 类 号：R459.7[医药卫生—急诊医学]