白细胞介素-1家族与炎性小体有关成员在心血管疾病中作用的研究进展  

Research progress on the role of interleukin-1 family and inflammasome-related members in cardiovascular diseases

作　　者：靳浩然 盛建龙[1] JIN Haoran;SHENG Jianlong(Department of Cardiology,the Second Hospital of Anhui Medical University,Hefei,230601,China)

机构地区：[1]安徽医科大学第二附属医院心血管内科,合肥230601

出　　处：《临床心血管病杂志》2025年第3期234-240,共7页Journal of Clinical Cardiology

基　　金：2021年度安徽省高校科学研究项目(No:KJ2021A0327)。

摘　　要：近些年,心血管疾病(cardiovascular disease,CVD)与炎症的关系被逐步阐明。在炎症过程中,炎性小体扮演着重要作用。炎性小体通过激活半胱天冬酶1(caspase-1)产生白细胞介素-1(interleukin-1,IL-1)家族成员IL-1β(interleukin-1β)、IL-18(interleukin-18)、IL-37(interleukin-37)。IL-1β、IL-18作为促炎因子参与炎症级联反应,引起CVD中的不良炎症反应;IL-37作为白细胞介素-1家族的新成员,通过阻断IL-1β、IL-18通路发挥炎症抑制因子的作用,在一定程度上延缓CVD的进展。针对上述靶点的抗炎治疗为CVD患者提供了一种可能的治疗策略。In recent years,the relationship between cardiovascular disease(CVD)and inflammation has been gradually elucidated.Inflammasome plays an important role in the inflammatory process.Inflammasome produces interleukin-1(IL-1)family members IL-1β,IL-18,and IL-37 by activating caspase-1.IL-1βand IL-18 participate in the inflammatory cascade as pro-inflammatory factors,causing adverse inflammatory responses in CVD;IL-37,as a new member of the interleukin-1 family,plays a role as an inflammation suppressor by blocking the IL-1βand IL-18 pathways,delaying the progression of CVD to a certain extent.CVD progression to a certain extent.Anti-inflammatory therapy targeting the above mentioned targets provides a possible diagnostic strategy for CVD patients.

关 键 词：白细胞介素37 白细胞介素18 白细胞介素1Β 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]