“脾胃升降协调论”针药结合法治疗非糜烂性反流病重叠功能性消化不良的临床疗效研究  

Clinical efficacy study of combination of acupuncture and medicine therapy based on"Coordination of Spleen and Stomach Ascending and Descending Theory"in treating non-erosive reflux disease overlapping with functional dyspepsia

作　　者：李双翼 时昭红[2] 张书[2] 张曼玲 LI Shuangyi;SHI Zhaohong;ZHANG Shu;ZHANG Manling(Hubei University of Chinese Medicine,Wuhan,430065,China;Department of Gastroenterology,Wuhan Hospital of Traditional Chinese and Western Medicine)

机构地区：[1]湖北中医药大学,武汉430065 [2]武汉市中西医结合医院消化内科

出　　处：《中国中西医结合消化杂志》2025年第3期268-273,共6页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家重点研发计划中医药现代化研究专项(No:2019YFC1709601,No:2019YFC1709604);国家中医临床基地拓展病种临床研究项目(No:JDZX2019001)。

摘　　要：目的:评价“脾胃升降协调论”针药结合法治疗非糜烂性反流病(non-erosive reflux disease,NERD)重叠功能性消化不良(functional dyspepsia,FD)的疗效和安全性。方法:选择2024年1月10日—2024年12月31日就诊于武汉市中西医结合医院消化内科门诊及住院部,诊断为NERD重叠FD的158例患者为研究对象,随机分为试验组与对照组,每组各79例。试验组予以半夏调中颗粒联合背俞针刺治疗,对照组予以泮托拉唑联合莫沙必利治疗,疗程均为4周。比较两组治疗前后临床疗效、GerdQ量表评分、高分辨率食管测压及胃电图指标,并以不良事件发生率进行安全性评价。结果:试验组的总有效率为88.6%(70/79),对照组为78.5%(62/79),两组差异无统计学意义(P>0.05)。与治疗前比较,两组治疗后的GerdQ量表评分、高分辨率食管测压指标LESP、DCI、DL、PA、PV,胃电图餐前/餐后的整体胃慢波百分比及PR均较治疗前下降(P<0.05)。与对照组比较,试验组的GerdQ量表评分、LESP、DCI、PA、PV、餐前/餐后的整体胃慢波百分比改善更明显(P<0.05)。结论:基于“脾胃升降协调论”的半夏调中颗粒联合背俞针刺针药结合法治疗NERD重叠FD疗效显著,且能改善患者食管及胃动力情况,临床应用安全可靠,值得推广。Objective To evaluate the efficacy and safety of combination of acupuncture and medicine therapy based on"Coordination of Spleen and Stomach Ascending and Descending Theory"in treating non-erosive reflux disease(NERD)overlapping with functional dyspepsia(FD).Methods A total of 158 patients diagnosed with NERD overlapping with FD who visited the outpatient and inpatient departments of the Department of Gastroenterology,Wuhan Hospital of Traditional Chinese and Western Medicine from January 10,2024 to November 31,2024 were randomly divided into the experimental and the control group,with 79 cases in each group.The experimental group was treated with Banxia Tiaozhong granules combined with Back-shu acupuncture,while the control group was treated with pantoprazole combined with mosapride.The treatment course for both groups was 4 weeks.The clinical efficacy,GerdQ scale scores,high-resolution esophageal manometry(HREM)and electrogastrography(EGG)indicators before and after treatment were compared between the two groups,and the safety was evaluated by the occurrence of adverse events.Results The total effective rate of the experimental group was 88.6%(70/79),and that of the control group was 78.5%(62/79),with no significant difference between the two groups(P>0.05).Compared with before treatment,the GerdQ scale scores,high-resolution esophageal manometry indicators LESP,DCI,DL,PA,PV,and the overall gastric slow wave percentage and PR of EGG before and after meals in both groups decreased after treatment(P<0.05).Compared with the control group,the improvement of GerdQ scale scores,LESP,DCI,PA,PV,and the overall gastric slow wave percentage before and after meals in the experimental group was more significant(P<0.05).Conclusion The combined therapy of Banxia Tiaozhong granules and Back-shu acupuncture based on the"Coordination of Spleen and Stomach Ascending and Descending Theory"has significant clinical efficacy in treating NERD overlapping with FD,improves esophageal and gastric motility,and is safe and reliable for ap

关 键 词：非糜烂性反流病 功能性消化不良 症状重叠 半夏调中颗粒 背俞针刺 

分 类 号：R256.3[医药卫生—中医内科学]