葛根黑苏汤联合通元针法对顽固性薄型子宫内膜患者临床疗效及妊娠情况的影响  

Effect of Gegen Heisu decoction combined with Tongyuan acupuncture on clinical efficacy and pregnancy of patients with refractory thin endometrium

作　　者：吴迪 WU Di(Department of Gynecology,Heze Traditional Chinese Medicine Hospital,Heze,Shandong,274000,China)

机构地区：[1]菏泽市中医医院妇科,山东菏泽274000

出　　处：《当代医学》2025年第1期47-52,共6页Contemporary Medicine

基　　金：山东省中医药科技项目(2021Q003)。

摘　　要：目的探究葛根黑苏汤联合通元针法对顽固性薄型子宫内膜患者临床疗效及妊娠率的影响。方法选取2020年3月至2022年9月菏泽市中医医院收治的90例顽固性薄型子宫内膜患者作为研究对象,按照随机数字表法分为中药组、针灸组、联合组,各30例。中药组给予葛根黑苏汤治疗,针灸组给予通元针法治疗,联合组给予葛根黑苏汤联合通元针法治疗,比较3组子宫内膜厚度及血流动力学指标[搏动指数(pulsatility index,PI)、阻力指数(resistance index,RI)、收缩期血流速度(peak systolic velocity,PSV)]、子宫内膜分型、雌激素[促卵泡刺激素(follicle stimulating hormone,FSH)、促黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E_(2))]水平、临床妊娠率。结果治疗后3个月,联合组子宫内膜厚度厚于中药组、针灸组,子宫内膜PI、RI均低于中药组、针灸组,子宫内膜PSV快于中药组、针灸组,差异有统计学意义(P<0.05),但中药组与针灸组子宫内膜厚度、PSV、PI、RI比较差异无统计学意义。治疗后3个月,联合组A型占比高于针灸组,C型占比低于针灸组,差异有统计学意义(P<0.05),联合组与中药组、中药组与针灸组A、C型占比比较差异均无统计学意义;3组B型占比比较差异均无统计学意义。治疗后3个月,联合组FSH、LH、E_(2)水平均高于中药组、针灸组,差异有统计学意义(P<0.05),但中药组与针灸组比较差异均无统计学意义。随访6个月,联合组临床妊娠率为30.00%,高于针灸组的3.33%,差异有统计学意义(P<0.017),联合组与中药组(6.67%)、中药组与针灸组临床妊娠率比较差异无统计学意义。结论与单纯应用葛根黑苏汤、通元针法治疗相比,葛根黑苏汤联合通元针法治疗顽固性薄型子宫内膜效果显著,可改善子宫内膜厚度、血流动力学水平、子宫内膜分型及雌激素水平,提高临床妊娠率。Objective To explore the effect of Gegen Heisu decoction combined with Tongyuan acupuncture on the clinical efficacy and pregnancy of patients with refractory thin endometrium.Methods 90 patients with refractory thin endometrium admitted to Heze Traditional Chinese Medicine Hospital from March 2020 to September 2022 were selected as the research subjects,and they were divided into the Traditional Chinese Medicine(TCM)group,acupuncture group and combined group according to random number table method,with 30 cases in each group.The TCM group was treated with Gegen Heisu decoction,the acupuncture group was treated with Tongyuan acupuncture,and the combined group was treated with Gegen Heisu decoction combined with Tongyuan acupuncture,the endometrial thickness and hemodynamic indexes(pulsatile index[PI],resistance index[RI],systolic blood flow velocity[PSV]),endometrial classification,estrogen(follicle-stimulating hormone[FSH],luteinizing hormone[LH],estradiol [E_(2)])levels,and clinical pregnancy rate were compared among the three groups.Results At three months after treatment,the thickness of endometrium in the combined group was thicker than that in the TCM group and the acupuncture group,the PI and RI of endometrium were lower than those in the TCM group and the acupuncture group,the PSV of endometrium was faster than that in the TCM group and the acupuncture group,the differences were statistically significant(P<0.05),but there was no statistically significant difference in endometrial thickness,PSV,PI and RI between the TCM group and the acupuncture group.At three months after treatment,the proportion of type A in the combined group was higher than that in the acupuncture group,and the proportion of type C was lower than that in the acupuncture group,the differences were statistically significant(P<0.05),there was no statistical significance in the proportion of type A and type C between combined group and TCM group,and between TCM group and acupuncture group;there was no significant difference in the proporti

关 键 词：顽固性薄型子宫内膜 葛根黑苏汤 通元针法 临床妊娠率 

分 类 号：R271.9[医药卫生—中西医结合]