津力达颗粒联合二甲双胍对老年2型糖尿病患者糖代谢及氧化应激的影响  

Effects of Jinlida granules combined with metformin on glucose metabolism and oxidative stress in elderly patients with type 2 diabetes mellitus

作　　者：胡凤[1] 徐咏书[1] 涂云明[1] HU Feng;XU Yongshu;TU Yunming(Department of Geriatrics,The Fourth Affiliated Hospital of Nanchang University,Nanchang,Jiangxi,330000,China)

机构地区：[1]南昌大学第四附属医院老年医学科,江西南昌330000

出　　处：《当代医学》2025年第1期68-72,共5页Contemporary Medicine

摘　　要：目的探讨津力达颗粒联合二甲双胍治疗老年2型糖尿病的临床价值。方法选取2021年3月至2022年1月南昌大学第四附属医院接收的106例老年2型糖尿病患者作为研究对象,采用随机数字表法分为对照组与观察组,各53例。对照组接受二甲双胍治疗,观察组在对照组基础上联合津力达颗粒治疗,比较两组糖脂代谢指标[空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(postprandial 2 h blood glucose,2 h PBG)、糖化血红蛋白Alc(glycosylated hemoglobin A1c,HbAlc)及甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)]、胰岛功能[空腹胰岛素(fasting insulin,FINS)、稳态模型评估-胰岛素抵抗指数(homeostasis model assessment of insulin resistance index,HOMA-IR)]、炎症因子[C反应蛋白(C-reactionprotein,CRP)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]水平、氧化应激指标[丙二醛(malondialdehyde,MDA)、谷胱甘肽过氧物酶(glutathione peroxidase,GSH-Px)]及不良反应发生情况。结果治疗后,观察组FBG、2 h PBG、HbAlc水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组TG、LDL-C水平均低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组FINS水平、HOMA-IR均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CRP、IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组MDA水平低于对照组,GSH-Px水平高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论津力达颗粒联合二甲双胍治疗老年2型糖尿病效果显著,可改善患者机体糖脂代谢,降低氧化应激水平,值得临床推广应用。Objective To explore the clinical value of Jinlida granules combined with metformin in the treatment of type 2 diabetes mellitus in the elderly.Methods 106 elderly patients with type 2 diabetes mellitus received by The Fourth Affiliated Hospital of Nanchang University from March 2021 to January 2022 were selected as the research subjects,and they were divided into the control group and the observation group according to random number table method,with 53 cases in each group.The control group received metformin treatment,and the observation group was treated combined with Jinlida granules on the basis of the control group,the glycolipid metabolism indicators(fasting blood glucose[FBG],postprandial 2 h blood glucose[2 h PBG],glycosylated hemoglobin A1c[HbAlc]and triglyceride[TG],low density lipoprotein cholesterol[LDL-C],high density lipoprotein cholesterol[HDL-C]),islet function(fasting insulin[FINS],homeostasis model assessment of insulin resistance index[HOMA-IR]),inflammatory factor(C-reactionprotein[CRP],interleukin-6[IL-6],tumor necrosis factor-α[TNF-α])levels,oxidative stress indicators(malondialdehyde[MDA],glutathione peroxidase[GSH-Px])and adverse reactions were compared betwen the two groups.Results After treatment,the levels of FBG,2 h PBG and HbAlc in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of TG and LDL-C in the observation group were lower than those in the control group,and the levels of HDL-C was higher than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of FINS and HOMA-IR in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of CRP,IL-6 and TNF-αin the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the MDA level in the observation group

关 键 词：津力达颗粒 二甲双胍 2型糖尿病 糖代谢 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]