艾博韦泰联合抗病毒治疗对艾滋病患者血浆人类免疫缺陷病毒RNA水平及免疫功能的影响  

Effects of albuvirtide combined with antiviral therapy on plasma human immunodeficiency virus RNA level and immune function in acquired immune deficiency syndrome patients

作　　者：邓龙文 杨晶 杨泉 DENG Longwen;YANG Jing;YANG Quan(Department of Infectious Disease,Ruijin People's Hospital,Ruijin,Jiangxi,342500,China)

机构地区：[1]瑞金市人民医院感染科,江西瑞金342500

出　　处：《当代医学》2025年第1期73-76,共4页Contemporary Medicine

摘　　要：目的探究艾博韦泰(albuvirtide,ABT)联合抗病毒治疗对艾滋病(acquired immune deficiency syndrome,AIDS)患者血浆人类免疫缺陷病毒(human immunodeficiency virus,HIV)RNA水平及免疫功能的影响。方法选取2020年11月至2022年8月瑞金市人民医院收治的66例AIDS患者作为研究对象,随机分为对照组与观察组,每组33例。对照组行抗病毒治疗,观察组予以ABT联合抗病毒治疗。比较两组临床疗效、多种机会感染发生情况、不良反应发生情况及HIV RNA、免疫功能及生化指标水平。结果观察组治疗总有效率为90.91%,高于对照组的69.70%,差异有统计学意义(P<0.05)。治疗3个月后,观察组HIV RNA、CD8^(+)水平均低于对照组,CD4^(+)水平高于对照组,差异有统计学意义(P<0.05)。治疗3个月后,观察组血红蛋白(hemoglobin,Hb)水平高于对照组,血肌酐(serum creatinine,SCr)、血尿酸(uric acid,UA)水平均低于对照组,差异有统计学意义(P<0.05)。观察组间质肺炎、念珠菌感染、皮肤结核相关感染、隐孢子虫相关腹泻的发生率均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论对AIDS患者行ABT联合抗病毒治疗,能在短期内快速降低HIV RNA水平,改善免疫功能,降低机会感染发生率,且安全性较高。Objective To investigate the effect of albuvirtide(ABT)combined with antiviral therapy on plasma human immunodeficiency virus(HIV)RNA level and immune function in acquired immune deficiency syndrome(AIDS)patients.Methods A total of 66 AIDS patients admitted to Ruijin People's Hospital from November 2020 to August 2022 were selected as the study subjects,and they were randomly divided into the control group and the observation group,with 33 cases in each group.The control group received antiviral therapy,and the observation group received ABT combined with antiviral therapy.The clinical efficacy,the occurrence of multiple opportunistic infections,the occurrence of adverse reactions,the levels of HIV RNA,immune function and biochemical indicators were compared between the two groups.Results The total effective rate in the observation group was 90.91%,which was higher than 69.70%in the control group,and the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of HIV RNA and CD8^(+)in the observation group were lower than those in the control group,and CD4^(+)was higher than those in the control group,and the differences were statistically significant(P<0.05).After 3 months of treatment,hemoglobin(Hb)level in the observation group was higher than that in the control group,serum creatinine(SCr)and uric acid(UA)levels were lower than those in the control group,the differences were statistically significant(P<0.05).The incidences of interstitial pneumonia,candida infection,cutaneous tuberculosis related infection and cryptosporidium related diarrhea in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion ABT combined with antiviral therapy for AIDS patients can rapidly reduce the level of HIV RNA,improve immune function and reduce the incidence of opportunistic infection in a short period of time,which has high

关 键 词：艾滋病 艾博韦泰 抗病毒 病毒载量 免疫功能 

分 类 号：R512.91[医药卫生—内科学]